Cardiovascular diseases are a growing problem in today’s society. The World Health Organization (WHO) reported that these diseases make up about 30% of total global deaths and that heart diseases have no geographic, gender or socioeconomic boundaries. Therefore, detecting cardiac irregularities early-stage and a correct treatment are very important. However, this requires a good physiological understanding of the cardiovascular system. The heart is stimulated electrically by the brain via the autonomic nervous system, where sympathetic and vagal pathways are always interacting and modulating heart rate. Continuous monitoring of the heart activity is obtained by means of an ElectroCardioGram (ECG). Studying the fluctuations of heart beat intervals over time reveals a lot of information and is called heart rate variability (HRV) analysis. A reduction of HRV has been reported in several cardiological and noncardiological diseases. Moreover, HRV also has a prognostic ...

The modern power grid is facing major challenges in the transition to a low-carbon energy sector. The growing energy demand and environmental concerns require carefully revisiting how electricity is generated, transmitted, and consumed, with an eye to the integration of renewable energy sources. The envisioned smart grid is expected to address such issues by introducing advanced information, control, and communication technologies into the energy infrastructure. In this context, demand-side management (DSM) makes the end users responsible for improving the efficiency, reliability and sustainability of the power system: this opens up unprecedented possibilities for optimizing the energy usage and cost at different levels of the network. The design of DSM techniques has been extensively discussed in the literature in the last decade, although the performance of these methods has been scarcely investigated from the analytical point of view. In this thesis, ...

Every year, an estimated 15 million babies are born preterm, that is, before 37 weeks of gestation. This number is rising in all countries and currently represents more than 1 in 10 babies, affecting families all over the world. During the last decades, the survival rate of prematurely born neonates has steadily increased, mainly as a result of medical and technical progress in neonatal intensive care. The very preterm infants, which represent up to 10% of the preterm infants in the EU, remain at risk for adverse outcome and neurodevelopmental disability. These maladaptive outcomes have a severe effect on the children’s quality of life and a huge economic impact on society. In order to reduce this burden and improve neonatal care in general, appropriate tools need to be developed to identify the neonates with a higher risk of adverse outcomes. ...

The present doctoral thesis aims towards the development of new long-term, multi-channel, audio-visual processing techniques for the analysis of bioacoustics phenomena. The effort is focused on the study of the physiology of the gastrointestinal system, aiming at the support of medical research for the discovery of gastrointestinal motility patterns and the diagnosis of functional disorders. The term "processing" in this case is quite broad, incorporating the procedures of signal processing, content description, manipulation and analysis, that are applied to all the recorded bioacoustics signals, the auxiliary audio-visual surveillance information (for the monitoring of experiments and the subjects' status), and the extracted audio-video sequences describing the abdominal sound-field alterations. The thesis outline is as follows. The main objective of the thesis, which is the technological support of medical research, is presented in the first chapter. A quick problem definition is initially ...

The cumulative impact of co-channel interferers, commonly referred to as aggregate network interference, is one of the main performance limiting factors in today’s mobile cellular networks. Thus, its careful statistical description is decisive for system analysis and design. A system model for interference analysis is required to capture essential network variation effects, such as base station deployment- and signal propagation characteristics. Furthermore it should be simple and tractable so as to enable first-order insights on design fundamentals and rapid exchange of new ideas. Interference modeling has posed a challenge ever since the establishment of traditional macro cellular deployments. The recent emergence of heterogeneous network topologies complicates matters by contesting many established aspects of time-honored approaches. This thesis presents user-centric system models that enable to investigate scenarios with an asymmetric interference impact. The first approach simplifies the interference analysis in a ...

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice, and one of the main causes of ictus and strokes. Despite the advances in the comprehension of its mechanisms, its thorough characterization and the quantification of its effects on the human heart are still an open issue. In particular, the choice of the most appropriate therapy is frequently a hard task. Radiofrequency catheter ablation (CA) is becoming one of the most popular solutions for the treatment of the disease. Yet, very little is known about its impact on heart substrate during AF, thus leading to an inaccurate selection of positive responders to therapy and a low success rate; hence, the need for advanced signal processing tools able to quantify AF impact on heart substrate and assess the effectiveness of the CA therapy in an objective and ...

The aim of this dissertation is the investigation of the key issues encountered in the development of wideband radio air-interfaces. Orthogonal frequency-division multiplexing (OFDM) is considered as the enabling technology for transmitting data at extremely high rates over time-dispersive radio channels. OFDM is a transmission scheme, which splits up the data stream, sending the data symbols simultaneously at a drastically reduced symbol rate over a set of parallel sub-carriers. The first part of this thesis deals with the modeling of the time-dispersive and frequency-selective radio channel, utilizing second order Gaussian stochastic processes. A novel channel measurement technique is developed, in which the RMS delay spread of the channel is estimated from the level-crossing rate of the frequency-selective channel transfer function. This method enables the empirical channel characterization utilizing simplified non-coherent measurements of the received power versus frequency. Air-interface and multiple ...

The purpose of this thesis is to describe novel signal processing methodologies and analog integrated circuit techniques for low-power biomedical systems. Physiological signals, such as the electrocardiogram (ECG), the electroencephalogram (EEG) and the electromyogram (EMG) are mostly non-stationary. The main difficulty in dealing with biomedical signal processing is that the information of interest is often a combination of features that are well localized temporally (e.g., spikes) and others that are more diffuse (e.g., small oscillations). This requires the use of analysis methods sufficiently versatile to handle events that can be at opposite extremes in terms of their time-frequency localization. Wavelet Transform (WT) has been extensively used in biomedical signal processing, mainly due to the versatility of the wavelet tools. The WT has been shown to be a very efficient tool for local analysis of nonstationary and fast transient signals due ...

The rate at which our heart beats, is a dynamical process enabling adaptive changes according to the demands of our body. These variations in heart rate are widely studied in so-called heart rate variability (HRV) analyses, as they contain much information about the activity of our autonomic nervous system. Variability in the heart rate arises from several processes, such as thermoregulation, hormones, arterial blood pressure, respiration, etc. One of the main short-term modulators of the heart rate is respiration. This phenomenon is called respiratory sinus arrhythmia (RSA) and comprises the rhythmic fluctuation of the heart rate at respiratory frequency. It has also widely been used as an index of vagal outflow. However, this has been widely debated as some studies have shown that the magnitude of RSA changes with respiratory rate and the depth of breathing, independently of parasympathetic activity. ...

The concept of fractional calculus has emerged as one of the most effective mathematical tools for improving the performance of electrical circuits and systems. By using this tool electronic filters, oscillators, integrators, differentiators, and several other signal processing circuits and systems are realized in fractional sense. Consequently, these systems are known as fractional-order systems, and they enjoy more degree of freedom. Fractional-order systems also have higher accuracy and flexibility than the conventional systems. The fractional-order systems utilize fractance devices (FDs) in place of conventional passive circuit components. Although these FDs are not available commercially as a lumped element; they can be approximated using a semi-infinite R-C/R-L tree or ladder network. These R-C/R-L networks based FDs degrade the performance of the overall system in terms of power efficiency, noise, circuit complexity, and cost, etc. In this work, an attempt has been ...

Mobile communications has become so successful today that conventional radio technologies, in traditional frequency bands below 6 GHz, are soon reaching their limits. To be able to develop massively deployed, ubiquitous, data-hungry, mobile applications, this study explores the use of higher frequency bands, or so-called millimeter waves in mobile communications. These radio bands above 30 GHz are mostly unoccupied and have dozens of gigahertz of bandwidth available. Moreover, advances in electronics have now made it possible to utilize these bands cost effectively. This thesis studied the millimeter wave wireless channel through conducting the following experiments: (1) two indoor millimeter wave measurement campaigns with directive horn antennas on both link ends, (2) an outdoor vehicular millimeter wave measurement campaign employing a horn antenna and an omni directional antenna, and (3) a railway communications ray-tracing study with directive antennas on both sides. ...

This thesis deals with the synchronization of one or several replicas of a known signal received in a scenario with multipath propagation and directional interference. A connecting theme along this work is the systematic application of the maximum likelihood (ML) principle together with a signal model in which the spatial signatures are unstructured and the noise term is Gaussian- distributed with an unknown correlation matrix. This last assumption is key in obtaining estimators that are capable of mitigating the disturbing signals that exhibit a certain structure, and this is achieved without resorting to the estimation of the parameters of those signals. On the other hand, the assumption of unstructured spatial signatures is interesting from a practical standpoint and facilitates the estimation problem since the estimates of these signatures can be obtained in closed form. This constitutes a first step towards ...

This thesis deals with the efficient and flexible acquisition and processing of spatial sound using multiple microphones. In spatial sound acquisition and processing, we use multiple microphones to capture the sound of multiple sources being simultaneously active at a rever- berant recording side and process the sound depending on the application at the application side. Typical applications include source extraction, immersive spatial sound reproduction, or speech enhancement. A flexible sound acquisition and processing means that we can capture the sound with almost arbitrary microphone configurations without constraining the application at the ap- plication side. This means that we can realize and adjust the different applications indepen- dently of the microphone configuration used at the recording side. For example in spatial sound reproduction, where we aim at reproducing the sound such that the listener perceives the same impression as if he ...

The respiratory sinus arrhythmia (RSA) is a form of cardiorespiratory coupling in which the heart rate accelerates during inhalation and decelerates during exhalation. Its quantification has been suggested as a tool to assess different diseases and conditions. However, whilst the potential of the RSA estimation as a diagnostic tool is shown in research works, its use in clinical practice and mobile applications is rather limited. This can be attributed to the lack of understanding of the mechanisms generating the RSA. To try to explain the RSA, studies are done using noninvasive signals, namely, respiration and heart rate variability (HRV), which are combined using different algorithms. Nevertheless, the algorithms are not standardized, making it difficult to draw solid conclusions from these studies. Therefore, the first aim of this thesis was to develop a framework to evaluate algorithms for RSA estimation. To ...

Reverberation consists of a complex acoustic phenomenon that occurs inside rooms. Many audio signal processing methods, addressing source localization, signal enhancement and other tasks, often assume absence of reverberation. Consequently, reverberant environments are considered challenging as state-ofthe-art methods can perform poorly. The acoustics of a room can be described using a variety of mathematical models, among which, physical models are the most complete and accurate. The use of physical models in audio signal processing methods is often non-trivial since it can lead to ill-posed inverse problems. These inverse problems require proper regularization to achieve meaningful results and involve the solution of computationally intensive large-scale optimization problems. Recently, however, sparse regularization has been applied successfully to inverse problems arising in different scientific areas. The increased computational power of modern computers and the development of new efficient optimization algorithms makes it possible ...