Machine learning and deep learning techniques have emerged as powerful tools for addressing complex challenges across diverse domains. These methodologies are powerful because they extract patterns and insights from large and complex datasets, automate decision-making processes, and continuously improve over time. They enable us to observe and quantify patterns in data that a normal human would not be able to capture, leading to deeper insights and more accurate predictions. This dissertation presents two research papers that leverage these methodologies to tackle distinct yet interconnected problems in neuroimaging and computer vision for the quantification of human health. The first investigation, "Age prediction using resting-state functional MRI," addresses the challenge of understanding brain aging. By employing the Least Absolute Shrinkage and Selection Operator (LASSO) on resting-state functional MRI (rsfMRI) data, we identify the most predictive correlations related to brain age. Our study, ...

The subject of this PhD thesis is the efficient and robust processing and analysis of the audio recordings that are derived from a call center. The thesis is comprised of two parts. The first part is dedicated to dialogue/non-dialogue detection and to speaker segmentation. The systems that are developed are prerequisite for detecting (i) the audio segments that actually contain a dialogue between the system and the call center customer and (ii) the change points between the system and the customer. This way the volume of the audio recordings that need to be processed is significantly reduced, while the system is automated. To detect the presence of a dialogue several systems are developed. This is the first effort found in the international literature that the audio channel is exclusively exploited. Also, it is the first time that the speaker utterance ...

This thesis contributes to motion characterization through inertial and physiological signals captured by wearable devices and analyzed using signal processing and deep learning techniques. This research leverages the possibilities of motion analysis for three main applications: to know what physical activity a person is performing (Human Activity Recognition), to identify who is performing that motion (user identification) or know how the movement is being performed (motor anomaly detection). Most previous research has addressed human motion modeling using invasive sensors in contact with the user or intrusive sensors that modify the user’s behavior while performing an action (cameras or microphones). In this sense, wearable devices such as smartphones and smartwatches can collect motion signals from users during their daily lives in a less invasive or intrusive way. Recently, there has been an exponential increase in research focused on inertial-signal processing to ...

Current Human-Machine Interfaces (HMI) lack of “emotional intelligence”, i.e. they are not able to identify human emotional states and take this information into account to decide on the proper actions to execute. The goal of affective computing is to fill this lack by detecting emotional cues occurring during Human-Computer Interaction (HCI) and synthesizing emotional responses. In the last decades, most of the studies on emotion assessment have focused on the analysis of facial expressions and speech to determine the emotional state of a person. Physiological activity also includes emotional information that can be used for emotion assessment but has received less attention despite of its advantages (for instance it can be less easily faked than facial expressions). This thesis reports on the use of two types of physiological activities to assess emotions in the context of affective computing: the activity ...

Slowly computers are being dressed and becoming huggable and tangible. They are being personalized and are expected to understand more of their users' feelings, emotions, and moods: This we refer to as affective computing. The work and experiences from 50+ publications on affective computing is collected and reported in one concise monograph. A brief introduction on emotion theory and affective computing is given and its relevance for computer science (i.e., Human-Computer Interaction, Artificial Intelligence (AI), and Health Informatics) is denoted. Next, a closed model for affective computing is introduced and reviews of both biosignals and affective computing are presented. The conclusion of all of this is that affective computing lacks standards. Affective computing's key dimensions need to be identified and studied to bring the field the progress it needs. A series of studies is presented that explore baseline-free affective computing, ...

Acutely-ill hospitalised patients are at risk of clinical deteriorations in health leading to adverse events such as cardiac arrests. Deteriorations are currently detected by manually measuring physiological parameters every 4-6 hours. Consequently, deteriorations can remain unrecognised between assessments, delaying clinical intervention. It may be possible to provide earlier detection of deteriorations by using wearable sensors for continuous physiological monitoring. Respiratory rate (RR) is not commonly monitored by wearable sensors, despite being a sensitive marker of deteriorations. This thesis presents investigations to identify an algorithm suitable for estimating RR from two signals commonly acquired by wearable sensors: the electrocardiogram (ECG) and photoplethysmogram (PPG). A suitable algorithm was then used to estimate RRs retrospectively from a physiological dataset acquired from acutely-ill patients to assess the potential utility of wearable sensors for detecting deteriorations. Existing RR algorithms were identi ed through a systematic ...

Cardiovascular diseases are a growing problem in today’s society. The World Health Organization (WHO) reported that these diseases make up about 30% of total global deaths and that heart diseases have no geographic, gender or socioeconomic boundaries. Therefore, detecting cardiac irregularities early-stage and a correct treatment are very important. However, this requires a good physiological understanding of the cardiovascular system. The heart is stimulated electrically by the brain via the autonomic nervous system, where sympathetic and vagal pathways are always interacting and modulating heart rate. Continuous monitoring of the heart activity is obtained by means of an ElectroCardioGram (ECG). Studying the fluctuations of heart beat intervals over time reveals a lot of information and is called heart rate variability (HRV) analysis. A reduction of HRV has been reported in several cardiological and noncardiological diseases. Moreover, HRV also has a prognostic ...

According to the Parkinson’s Foundation, more than 10 million people world- wide suffer from Parkinson’s disease (PD). The common symptoms are tremor, muscle rigidity and slowness of movement. There is no cure available cur- rently, but clinical intervention can help alleviate the symptoms significantly. Recently, it has been found that PD can be detected and telemonitored by voice signals, such as sustained phonation /a/. However, the voiced-based PD detector suffers from severe performance degradation in adverse envi- ronments, such as noise, reverberation and nonlinear distortion, which are common in uncontrolled settings. In this thesis, we focus on deriving speech modeling and robust estima- tion algorithms capable of improving the PD detection accuracy in adverse environments. Robust estimation algorithms using parametric modeling of voice signals are proposed. We present both segment-wise and sample-wise robust pitch tracking algorithms using the harmonic model. ...

In this thesis, the power of Machine Learning (ML) algorithms is combined with brain connectivity patterns, using Magnetic Resonance Imaging (MRI), for classification and prediction of Multiple Sclerosis (MS). White Matter (WM) as well as Grey Matter (GM) graphs are studied as connectome data types. The thesis addresses three main research objectives. The first objective aims to generate realistic brain connectomes data for improving the classification of MS clinical profiles in cases of data scarcity and class imbalance. To solve the problem of limited and imbalanced data, a Generative Adversarial Network (GAN) was developed for the generation of realistic and biologically meaningful connec- tomes. This network achieved a 10% better MS classification performance compared to classical approaches. As second research objective, we aim to improve classification of MS clinical profiles us- ing morphological features only extracted from GM brain tissue. ...

The recent progress in artificial neural networks (rebranded as “deep learning”) has significantly boosted the state-of-the-art in numerous domains of computer vision offering an opportunity to approach the problems which were hardly solvable with conventional machine learning. Thus, in the frame of this PhD study, we explore how deep learning techniques can help in the analysis of one the most basic and essential semantic traits revealed by a human face, namely, gender and age. In particular, two complementary problem settings are considered: (1) gender/age prediction from given face images, and (2) synthesis and editing of human faces with the required gender/age attributes. Convolutional Neural Network (CNN) has currently become a standard model for image-based object recognition in general, and therefore, is a natural choice for addressing the first of these two problems. However, our preliminary studies have shown that the ...

Obstructive sleep apnea (OSA) is among the most prevalent sleep disorders, which is estimated to affect 6 %−19 % of women and 13 %−33 % of men. Besides daytime sleepiness, impaired cognitive functioning and an increased risk for accidents, OSA may lead to obesity, diabetes and cardiovascular diseases (CVD) on the long term. Its prevalence is only expected to rise, as it is linked to aging and excessive body fat. Nevertheless, many patients remain undiagnosed and untreated due to the cumbersome clinical diagnostic procedures. For this, the patient is required to sleep with an extensive set of body attached sensors. In addition, the recordings only provide a single night perspective on the patient in an uncomfortable, and often unknown, environment. Thus, large scale monitoring at home is desired with comfortable sensors, which can stay in place for several nights. To ...

This thesis faces the problem of automatically classifying environmental sounds, i.e., any non-speech or non-music sounds that can be found in the environment. Broadly speaking, two main processes are needed to perform such classification: the signal feature extraction so as to compose representative sound patterns and the machine learning technique that performs the classification of such patterns. The main focus of this research is put on the former, studying relevant signal features that optimally represent the sound characteristics since, according to several references, it is a key issue to attain a robust recognition. This type of audio signals holds many differences with speech or music signals, thus specific features should be determined and adapted to their own characteristics. In this sense, new signal features, inspired by the human auditory system and the human perception of sound, are proposed to improve ...

The respiratory sinus arrhythmia (RSA) is a form of cardiorespiratory coupling in which the heart rate accelerates during inhalation and decelerates during exhalation. Its quantification has been suggested as a tool to assess different diseases and conditions. However, whilst the potential of the RSA estimation as a diagnostic tool is shown in research works, its use in clinical practice and mobile applications is rather limited. This can be attributed to the lack of understanding of the mechanisms generating the RSA. To try to explain the RSA, studies are done using noninvasive signals, namely, respiration and heart rate variability (HRV), which are combined using different algorithms. Nevertheless, the algorithms are not standardized, making it difficult to draw solid conclusions from these studies. Therefore, the first aim of this thesis was to develop a framework to evaluate algorithms for RSA estimation. To ...

The provision of accurate positioning is becoming essential to our modern society. One of the main reasons is the great success and ease of use of Global Navigation Satellite Systems (GNSSs), which has led to an unprecedented amount of GNSS-based applications. In particular, the current trend shows that a new era of GNSS-based applications and services is emerging. These applications are the so-called critical applications, in which the physical safety of users may be in danger due to a miss-performance of the positioning system. These applications have very stringent requirements in terms of integrity. Integrity is a measure of reliability and trust that can be placed on the information provided by the system. Integrity algorithms were originally designed for civil aviation in the 1980s. Unfortunately, GNSS-based critical applications are often associated with terrestrial environments and original integrity algorithms usually fail. ...

Cancer, with its varying and hard to detect types, became one of the most dangerous diseases for humans. Melanoma is a type of skin cancer that has the most mortality rate among its type. The usual melanoma detection process is based on awareness of the patient and the experience of the visual investigator. Even though the invention of dermoscopes reduce its effects, “subjectivity” problem plays a huge role on the detection accuracy, which creates a need for automated detection. In this thesis, history of automated melanoma detection on dermoscopic images and caveats of present frameworks are studied. Different approaches to overcome these caveats are explored. As a result, a new melanoma detection algorithm based on Bag of Visual Words (BoVW) concept, which combines traditional methods with new age deep learning techniques, is created. The performance of the new algorithm is ...