Central and peripheral mechanisms: a multimodal approach to understanding and restoring human motor control (2020)
Abstract / truncated to 115 words
All human actions involve motor control. Even the simplest movement requires the coordinated recruitment of many muscles, orchestrated by neuronal circuits in the brain and the spinal cord. As a consequence, lesions affecting the central nervous system, such as stroke, can lead to a wide range of motor impairments. While a certain degree of recovery can often be achieved by harnessing the plasticity of the motor hierarchy, patients typically struggle to regain full motor control. In this context, technology-assisted interventions offer the prospect of intense, controllable and quantifiable motor training. Yet, clinical outcomes remain comparable to conventional approaches, suggesting the need for a paradigm shift towards customized knowledge-driven treatments to fully exploit their potential. In ... toggle 7 keywordshuman motor control – spinal cord – functional magnetic resonance imaging – dynamic functional connectivity – neurotechnology – neurorehabilitation – stroke
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