The term "spike" is used to describe a short-time event that is the result of the activity of its source. Spikes can be seen in different signal modalities. In these modalities, often more than one source generates spikes. Classification algorithms can be used to group similar spikes, ideally spikes from the same source. This work examines the classification of spikes generated from neurons and muscles. When each detected spike is assigned to its source, the spike trains of these sources can provide information on complex brain network functioning, muscle disorders, and other applications. During the past several decades, there were many attempts to create and improve spike classification algorithms. No matter how advanced these methods are today, errors in classification cannot be avoided. Therefore, methods that would determine and improve reliability of classification are very desirable. In this work, it ...

Surface electromyography (sEMG) has become an indispensable tool, extensively used across various fields such as medical diagnosis, rehabilitation, sports science, and prosthetic control. Among these applications, the study of neuromuscular adaptations related to muscle fatigue stands out due to its complexity and the intricate physiological processes underlying muscle activity. This PhD thesis aims to address this challenge by exploring the use of bipolar and high-density surface EMG (HD-EMG) to study the electrical signs of muscle fatigue across different scenarios. The primary objective is to advance our understanding of the neuromuscular system's strategies during fatigue and to use non-invasive sEMG as a reliable method for accurately detecting and characterizing the progression of muscle fatigue. This research is structured around several key questions addressing different aspects of muscle fatigue assessment. The first part focuses on evaluating various spectral estimation techniques, as changes ...

Work-related musculoskeletal disorders are a growing problem in todays society. These musculoskeletal disorders are caused by, amongst others, repetitive movements and mental stress. Stress is defined as the mismatch between a perceived demand and the perceived capacities to meet this demand. Although stress has a subjective origin, several physiological manifestations (e.g. cardiovascular and muscular) occur during periods of perceived stress. New insight and algorithms to extract information, related to stress are beneficial. Therefore, two series of stress experiments are executed in a laboratory environment, where subjects underwent different tasks inducing physical strain, mental stress and a combination of both. In this manuscript, new and modified algorithms for electromyography signals are presented that improve the individual analysis of electromyography signals. A first algorithm removes the interference of the electrical activity of the heart on singlechannel electromyography measurements. This interference signal is ...

Diffusion Magnetic Resonance Imaging (dMRI) is a meaningful technique for white matter (WM) fiber-tracking and microstructural characterization of axonal/neuronal integrity and connectivity. By measuring water molecules motion in the three directions of space, numerous parametric maps can be reconstructed. Among these, fractional anisotropy (FA), mean diffusivity (MD), and axial (λa) and radial (λr) diffusivities have extensively been used to investigate brain diseases. Overall, these findings demonstrated that WM and grey matter (GM) tissues are subjected to numerous microstructural alterations in multiple sclerosis (MS). However, it remains unclear whether these tissue alterations result from global processes, such as inflammatory cascades and/or neurodegenerative mechanisms, or local inflammatory and/or demyelinating lesions. Furthermore, these pathological events may occur along afferent or afferent WM fiber pathways, leading to antero- or retrograde degeneration. Thus, for a better understanding of MS pathological processes like its spatial and ...

The level of automation in our society is ever increasing. Technologies like self-driving cars, virtual reality, and fully autonomous robots, which all were unimaginable a few decades ago, are realizable today, and will become standard consumer products in the future. These technologies depend upon autonomous localization and situation awareness where careful processing of sensory data is required. To increase efficiency, robustness and reliability, appropriate models for these data are needed. In this thesis, such models are analyzed within three different application areas, namely (1) magnetic localization, (2) extended target tracking, and (3) autonomous learning from raw pixel information. Magnetic localization is based on one or more magnetometers measuring the induced magnetic field from magnetic objects. In this thesis we present a model for determining the position and the orientation of small magnets with an accuracy of a few millimeters. This ...

All human actions involve motor control. Even the simplest movement requires the coordinated recruitment of many muscles, orchestrated by neuronal circuits in the brain and the spinal cord. As a consequence, lesions affecting the central nervous system, such as stroke, can lead to a wide range of motor impairments. While a certain degree of recovery can often be achieved by harnessing the plasticity of the motor hierarchy, patients typically struggle to regain full motor control. In this context, technology-assisted interventions offer the prospect of intense, controllable and quantifiable motor training. Yet, clinical outcomes remain comparable to conventional approaches, suggesting the need for a paradigm shift towards customized knowledge-driven treatments to fully exploit their potential. In this thesis, we argue that a detailed understanding of healthy and impaired motor pathways can foster the development of therapies optimally engaging plasticity. To this ...

Turkish, being an agglutinative language with rich morphology, presents challenges for Large Vocabulary Continuous Speech Recognition (LVCSR) systems. First, the agglutinative nature of Turkish leads to a high number of Out-of Vocabulary (OOV) words which in turn lower Automatic Speech Recognition (ASR) accuracy. Second, Turkish has a relatively free word order that leads to non-robust language model estimates. These challenges have been mostly handled by using meaningful segmentations of words, called sub-lexical units, in language modeling. However, a shortcoming of sub-lexical units is over-generation which needs to be dealt with for higher accuracies. This dissertation aims to address the challenges of Turkish in LVCSR. Grammatical and statistical sub-lexical units for language modeling are investigated and they yield substantial improvements over the word language models. Our novel approach inspired by dynamic vocabulary adaptation mostly recovers the errors caused by over-generation and ...

The subject of this PhD thesis is the efficient and robust processing and analysis of the audio recordings that are derived from a call center. The thesis is comprised of two parts. The first part is dedicated to dialogue/non-dialogue detection and to speaker segmentation. The systems that are developed are prerequisite for detecting (i) the audio segments that actually contain a dialogue between the system and the call center customer and (ii) the change points between the system and the customer. This way the volume of the audio recordings that need to be processed is significantly reduced, while the system is automated. To detect the presence of a dialogue several systems are developed. This is the first effort found in the international literature that the audio channel is exclusively exploited. Also, it is the first time that the speaker utterance ...

In the modern world, we are increasingly surrounded by computation devices with communication links and one or more microphones. Such devices are, for example, smartphones, tablets, laptops or hearing aids. These devices can work together as nodes in an acoustic sensor network (ASN). Such networks are a growing platform that opens the possibility for many practical applications. ASN based speech enhancement, source localization, and event detection can be applied for teleconferencing, camera control, automation, or assisted living. For this kind of applications, the awareness of auditory objects and their spatial positioning are key properties. In order to provide these two kinds of information, novel methods have been developed in this thesis. Information on the type of auditory objects is provided by a novel real-time sound classification method. Information on the position of human speakers is provided by a novel localization ...

Epilepsy is one of the most common neurological diseases that manifests in repetitive epileptic seizures as a result of an abnormal, synchronous activity of a large group of neurons. Depending on the affected brain regions, seizures produce various severe clinical symptoms. There is no cure for epilepsy and sometimes even medication and other therapies, like surgery, vagus nerve stimulation or ketogenic diet, do not control the number of seizures. In that case, long-term (home) monitoring and automatic seizure detection would enable the tracking of the evolution of the disease and improve objective insight in any responses to medical interventions or changes in medical treatment. Especially during the night, supervision is reduced; hence a large number of seizures is missed. In addition, an alarm should be integrated into the automated seizure detection algorithm for severe seizures in order to help the ...

The interest for the intelligent vehicle field has been increased during the last years, must probably due to an important number of road accidents. Many accidents could be avoided if a device attached to the vehicle would assist the driver with some warnings when dangerous situations are about to appear. In recent years, leading car developers have recorded significant efforts and support research works regarding the intelligent vehicle field where they propose solutions for the existing problems, especially in the vision domain. Road detection and following, pedestrian or vehicle detection, recognition and tracking, night vision, among others are examples of applications which have been developed and improved recently. Still, a lot of challenges and unsolved problems remain in the intelligent vehicle domain. Our purpose in this thesis is to design an Obstacle Recognition system for improving the road security by ...

The brain is the most important signal processing unit in the human body. It is responsible for receiving, processing and storing information. One of the possibilities to study brain functioning is by placing electrodes on the scalp and recording the synchronous neuronal activity of the brain. Such a recording measures a combination of active processes in the whole brain. Unfortunately, it is also contaminated by artifacts. By extracting the artifacts and removing them, cleaned recordings can be investigated. Furthermore, it is easier to look at specific brain activities, like an epileptic seizure, than at a combination. In this thesis, we present different mathematical techniques that can be used to extract individual contributing sources from the measured signals for this purpose. We focused on Canonical Correlation Analysis (CCA), Independent Component Analysis (ICA) and Canonical/ Parallel Factor Analysis (CPA). We show that ...

According to the Parkinson’s Foundation, more than 10 million people world- wide suffer from Parkinson’s disease (PD). The common symptoms are tremor, muscle rigidity and slowness of movement. There is no cure available cur- rently, but clinical intervention can help alleviate the symptoms significantly. Recently, it has been found that PD can be detected and telemonitored by voice signals, such as sustained phonation /a/. However, the voiced-based PD detector suffers from severe performance degradation in adverse envi- ronments, such as noise, reverberation and nonlinear distortion, which are common in uncontrolled settings. In this thesis, we focus on deriving speech modeling and robust estima- tion algorithms capable of improving the PD detection accuracy in adverse environments. Robust estimation algorithms using parametric modeling of voice signals are proposed. We present both segment-wise and sample-wise robust pitch tracking algorithms using the harmonic model. ...

Sparsity-based estimation techniques deal with the problem of retrieving a data vector from an undercomplete set of linear observations, when the data vector is known to have few nonzero elements with unknown positions. It is also known as the atomic decomposition problem, and has been carefully studied in the field of compressed sensing. Recent findings have led to a method called basis pursuit, also known as Least Absolute Shrinkage and Selection Operator (LASSO), as a numerically reliable sparsity-based approach. Although the atomic decomposition problem is generally NP-hard, it has been shown that basis pursuit may provide exact solutions under certain assumptions. This has led to an extensive study of signals with sparse representation in different domains, providing a new general insight into signal processing. This thesis further investigates the role of sparsity-based techniques, especially basis pursuit, for solving parameter estimation ...

The purpose of this thesis is to describe novel signal processing methodologies and analog integrated circuit techniques for low-power biomedical systems. Physiological signals, such as the electrocardiogram (ECG), the electroencephalogram (EEG) and the electromyogram (EMG) are mostly non-stationary. The main difficulty in dealing with biomedical signal processing is that the information of interest is often a combination of features that are well localized temporally (e.g., spikes) and others that are more diffuse (e.g., small oscillations). This requires the use of analysis methods sufficiently versatile to handle events that can be at opposite extremes in terms of their time-frequency localization. Wavelet Transform (WT) has been extensively used in biomedical signal processing, mainly due to the versatility of the wavelet tools. The WT has been shown to be a very efficient tool for local analysis of nonstationary and fast transient signals due ...