Magnetic Resonance Spectroscopy (MRS) is a technique which has evolved rapidly over the past 15 years. It has been used specifically in the context of brain tumours and has shown very encouraging correlations between brain tumour type and spectral pattern. In vivo MRS enables the quantification of metabolite concentrations non-invasively, thereby avoiding serious risks to brain damage. While Magnetic Resonance Imaging (MRI) is commonly used for identifying the location and size of brain tumours, MRS complements it with the potential to provide detailed chemical information about metabolites present in the brain tissue and enable an early detection of abnormality. However, the introduction of MRS in clinical medicine has been difficult due to problems associated with the acquisition of in vivo MRS signals from living tissues at low magnetic fields acceptable for patients. The low signal-to-noise ratio makes accurate analysis of ...

We consider Bayesian networks (BNs) with discriminatively optimized parameters and structures, i.e. BNs that are optimized to maximize a kind of probabilistic margin. These maximum margin Bayesian networks (MM BNs) are inspired by support vector machines (SVMs) that aim to separate samples from different classes by a large margin in some feature space. MM BNs achieve classification performance on par with BNs optimized according to other discriminative criteria, e.g. maximum conditional likelihood. Furthermore, in several applications, they achieve classification performance comparable to that of both, linear and kernelized, SVMs. In the literature, two definitions of MM BNs with respect to their parameters are available. We analyze these definitions in terms of asymptotic consistency, extend these definitions by a generative regularizer and analyze properties of MM BNs with respect to reduced-precision implementations. We start by analyzing the asymptotic consistency of MM ...

The interest for the intelligent vehicle field has been increased during the last years, must probably due to an important number of road accidents. Many accidents could be avoided if a device attached to the vehicle would assist the driver with some warnings when dangerous situations are about to appear. In recent years, leading car developers have recorded significant efforts and support research works regarding the intelligent vehicle field where they propose solutions for the existing problems, especially in the vision domain. Road detection and following, pedestrian or vehicle detection, recognition and tracking, night vision, among others are examples of applications which have been developed and improved recently. Still, a lot of challenges and unsolved problems remain in the intelligent vehicle domain. Our purpose in this thesis is to design an Obstacle Recognition system for improving the road security by ...

This thesis has two main parts. The first part deals with security and privacy analysis of biometric hashing. The second part introduces a method for fixed-length feature vector extraction and hash generation from fingerprint minutiae. The upsurge of interest in biometric systems has led to development of biometric template protection methods in order to overcome security and privacy problems. Biometric hashing produces a secure binary template by combining a personal secret key and the biometric of a person, which leads to a two factor authentication method. This dissertation analyzes biometric hashing both from a theoretical point of view and in regards to its practical application. For theoretical evaluation of biohashes, a systematic approach which uses estimated entropy based on degree of freedom of a binomial distribution is outlined. In addition, novel practical security and privacy attacks against face image hashing ...

The present doctoral thesis aims towards the development of new long-term, multi-channel, audio-visual processing techniques for the analysis of bioacoustics phenomena. The effort is focused on the study of the physiology of the gastrointestinal system, aiming at the support of medical research for the discovery of gastrointestinal motility patterns and the diagnosis of functional disorders. The term "processing" in this case is quite broad, incorporating the procedures of signal processing, content description, manipulation and analysis, that are applied to all the recorded bioacoustics signals, the auxiliary audio-visual surveillance information (for the monitoring of experiments and the subjects' status), and the extracted audio-video sequences describing the abdominal sound-field alterations. The thesis outline is as follows. The main objective of the thesis, which is the technological support of medical research, is presented in the first chapter. A quick problem definition is initially ...

Signature verification deals with the problem of identifying forged signatures of a user from his/her genuine signatures. The difficulty lies in identifying allowed variations in a user’s signatures, in the presence of high intra-class and low inter-class variability (the forgeries may be more similar to a user’s genuine signature, compared to his/her other genuine signatures). The problem can be seen as a non-rigid object matching where classes are very similar. In the field of biometrics, signature is considered a behavioral biometric and the problem possesses further difficulties compared to other modalities (e.g. fingerprints) due to the added issue of skilled forgeries. A novel offline (image-based) signature verification system is proposed in this thesis. In order to capture the signature’s stable parts and alleviate the difficulty of global matching, local features (histogram of oriented gradients, local binary patterns) are used, based ...

The first part of this dissertation considers distributed learning problems over networked agents. The general objective of distributed adaptation and learning is the solution of global, stochastic optimization problems through localized interactions and without information about the statistical properties of the data. Regularization is a useful technique to encourage or enforce structural properties on the resulting solution, such as sparsity or constraints. A substantial number of regularizers are inherently non-smooth, while many cost functions are differentiable. We propose distributed and adaptive strategies that are able to minimize aggregate sums of objectives. In doing so, we exploit the structure of the individual objectives as sums of differentiable costs and non-differentiable regularizers. The resulting algorithms are adaptive in nature and able to continuously track drifts in the problem; their recursions, however, are subject to persistent perturbations arising from the stochastic nature of ...

Advanced nuclear medical imaging systems collect multiple attributes of a large number of photon events, resulting in extremely large datasets which present challenges to image reconstruction and assessment. This dissertation addresses several of these challenges. The image formation process in nuclear medical imaging can be posed as a parametric estimation problem where the image pixels are the parameters of interest. Since nuclear medical imaging applications are often ill-posed inverse problems, unbiased estimators result in very noisy, high-variance images. Typically, smoothness constraints and a priori information are used to reduce variance in medical imaging applications at the cost of biasing the estimator. For such problems, there exists an inherent tradeoff between the recovered spatial resolution of an estimator, overall bias, and its statistical variance; lower variance can only be bought at the price of decreased spatial resolution and/or increased overall bias. ...

Advances in compression techniques, decreasing cost of storage, and high-speed transmission have facilitated the way videos are created, stored and distributed. As a consequence, videos are now being used in many applications areas. The increase in the amount of video data deployed and used in today's applications reveals not only the importance as multimedia data type, but also led to the requirement of efficient management of video data. This management paved the way for new research areas, such as indexing and retrieval of video with respect to their spatio-temporal, visual and semantic contents. This thesis presents work towards a unified framework for semi-automated video indexing and interactive retrieval. To create an efficient index, a set of representative key frames are selected which capture and encapsulate the entire video content. This is achieved by, firstly, segmenting the video into its constituent ...

Nowadays, diagnosis and treatment of brain tumors is based on clinical symptoms, radiological appearance, and often histopathology. Magnetic resonance imaging (MRI) is a major noninvasive tool for the anatomical assessment of tumors in the brain. However, several diagnostic questions, such as the type and grade of the tumor, are difficult to address using MRI. The histopathology of a tissue specimen remains the gold standard, despite the associated risks of surgery to obtain a biopsy. In recent years, the use of magnetic resonance spectroscopy (MRS), which provides a metabolic profile, has gained a lot of interest for a more detailed and specific noninvasive evaluation of brain tumors. In particular, magnetic resonance spectroscopic imaging (MRSI) is attractive as this may also enable to visualize the heterogeneous spatial extent of tumors, both inside and outside the MRI detectable lesion. As manual, individual, viewing ...

This doctoral thesis focuses on the development of algorithms of speaker characterisation by voice. Namely, characterisation of speaker’s identity, and the emotional state detectable in his voice while using the application of state-of-the art classifier algorithm Support Vector Machine (SVM) will be discussed. The first part deals with the state of the art SVM classifier utilised for classification experiments where we search for more sophisticated form of SVM model parameters selection. Also, we successfully apply optimization methods (PSO and GA algorithm) on two classification problems. The second part of this thesis deal with emotion recognition in continuous/dimensional space.

In this doctoral thesis several scale-free texture segmentation procedures based on two fractal attributes, the Hölder exponent, measuring the local regularity of a texture, and local variance, are proposed.A piecewise homogeneous fractal texture model is built, along with a synthesis procedure, providing images composed of the aggregation of fractal texture patches with known attributes and segmentation. This synthesis procedure is used to evaluate the proposed methods performance.A first method, based on the Total Variation regularization of a noisy estimate of local regularity, is illustrated and refined thanks to a post-processing step consisting in an iterative thresholding and resulting in a segmentation.After evidencing the limitations of this first approach, deux segmentation methods, with either "free" or "co-located" contours, are built, taking in account jointly the local regularity and the local variance.These two procedures are formulated as convex nonsmooth functional minimization problems.We ...

The use of machine-learning for multimedia forensics is gaining more and more consensus, especially due to the amazing possibilities offered by modern machine learning techniques. By exploiting deep learning tools, new approaches have been proposed whose performance remarkably exceed those achieved by state-of-the-art methods based on standard machine-learning and model-based techniques. However, the inherent vulnerability and fragility of machine learning architectures pose new serious security threats, hindering the use of these tools in security-oriented applications, and, among them, multimedia forensics. The analysis of the security of machine learning-based techniques in the presence of an adversary attempting to impede the forensic analysis, and the development of new solutions capable to improve the security of such techniques is then of primary importance, and, recently, has marked the birth of a new discipline, named Adversarial Machine Learning. By focusing on Image Forensics and ...

Due to a variety of potential barriers to sample acquisition, many of the datasets encountered in important classification applications, ranging from tumor identification to facial recognition, are characterized by small samples of high-dimensional data. In such situations, linear classifiers are popular as they have less risk of overfitting while being faster and more interpretable than non-linear classifiers. They are also easier to understand and implement for the inexperienced practitioner. In this dissertation, several gaps in the literature regarding the analysis and design of linear classifiers for high-dimensional data are addressed using tools from the field of asymptotic Random Matrix Theory (RMT) which facilitate the derivation of limits of relevant quantities or distributions, such as the probability of misclassification of a particular classifier or the asymptotic distribution of its discriminant, in the RMT regime where both the sample size and dimensionality ...

This dissertation is concerned with the design and analysis of approximation-based methods for nonconvex nonsmooth optimization problems. The main idea behind those methods is to solve a difficult optimization problem by converting it into a sequence of simpler surrogate/approximate problems. In the two widely-used optimization frameworks, namely, the majorization-minimization (MM) framework and the successive convex approximation (SCA) framework, the approximate function is designed to be a global upper bound, called majorizer, of the original objective function and convex, respectively. Generally speaking, there are two desiderata of the approximate function, i.e., the tightness to the original objective function and the low computational complexity of minimizing the approximate function. In particular, we focus on techniques that can be used to construct a parallelizable approximate problem so as to take advantage of modern multicore computing platforms. The first part of this thesis aims ...