Magnetic Resonance Spectroscopy (MRS) is a technique which has evolved rapidly over the past 15 years. It has been used specifically in the context of brain tumours and has shown very encouraging correlations between brain tumour type and spectral pattern. In vivo MRS enables the quantification of metabolite concentrations non-invasively, thereby avoiding serious risks to brain damage. While Magnetic Resonance Imaging (MRI) is commonly used for identifying the location and size of brain tumours, MRS complements it with the potential to provide detailed chemical information about metabolites present in the brain tissue and enable an early detection of abnormality. However, the introduction of MRS in clinical medicine has been difficult due to problems associated with the acquisition of in vivo MRS signals from living tissues at low magnetic fields acceptable for patients. The low signal-to-noise ratio makes accurate analysis of ...

Advanced nuclear medical imaging systems collect multiple attributes of a large number of photon events, resulting in extremely large datasets which present challenges to image reconstruction and assessment. This dissertation addresses several of these challenges. The image formation process in nuclear medical imaging can be posed as a parametric estimation problem where the image pixels are the parameters of interest. Since nuclear medical imaging applications are often ill-posed inverse problems, unbiased estimators result in very noisy, high-variance images. Typically, smoothness constraints and a priori information are used to reduce variance in medical imaging applications at the cost of biasing the estimator. For such problems, there exists an inherent tradeoff between the recovered spatial resolution of an estimator, overall bias, and its statistical variance; lower variance can only be bought at the price of decreased spatial resolution and/or increased overall bias. ...

This thesis has two main parts. The first part deals with security and privacy analysis of biometric hashing. The second part introduces a method for fixed-length feature vector extraction and hash generation from fingerprint minutiae. The upsurge of interest in biometric systems has led to development of biometric template protection methods in order to overcome security and privacy problems. Biometric hashing produces a secure binary template by combining a personal secret key and the biometric of a person, which leads to a two factor authentication method. This dissertation analyzes biometric hashing both from a theoretical point of view and in regards to its practical application. For theoretical evaluation of biohashes, a systematic approach which uses estimated entropy based on degree of freedom of a binomial distribution is outlined. In addition, novel practical security and privacy attacks against face image hashing ...

The first part of this dissertation considers distributed learning problems over networked agents. The general objective of distributed adaptation and learning is the solution of global, stochastic optimization problems through localized interactions and without information about the statistical properties of the data. Regularization is a useful technique to encourage or enforce structural properties on the resulting solution, such as sparsity or constraints. A substantial number of regularizers are inherently non-smooth, while many cost functions are differentiable. We propose distributed and adaptive strategies that are able to minimize aggregate sums of objectives. In doing so, we exploit the structure of the individual objectives as sums of differentiable costs and non-differentiable regularizers. The resulting algorithms are adaptive in nature and able to continuously track drifts in the problem; their recursions, however, are subject to persistent perturbations arising from the stochastic nature of ...

Nowadays, diagnosis and treatment of brain tumors is based on clinical symptoms, radiological appearance, and often histopathology. Magnetic resonance imaging (MRI) is a major noninvasive tool for the anatomical assessment of tumors in the brain. However, several diagnostic questions, such as the type and grade of the tumor, are difficult to address using MRI. The histopathology of a tissue specimen remains the gold standard, despite the associated risks of surgery to obtain a biopsy. In recent years, the use of magnetic resonance spectroscopy (MRS), which provides a metabolic profile, has gained a lot of interest for a more detailed and specific noninvasive evaluation of brain tumors. In particular, magnetic resonance spectroscopic imaging (MRSI) is attractive as this may also enable to visualize the heterogeneous spatial extent of tumors, both inside and outside the MRI detectable lesion. As manual, individual, viewing ...

The use of machine-learning for multimedia forensics is gaining more and more consensus, especially due to the amazing possibilities offered by modern machine learning techniques. By exploiting deep learning tools, new approaches have been proposed whose performance remarkably exceed those achieved by state-of-the-art methods based on standard machine-learning and model-based techniques. However, the inherent vulnerability and fragility of machine learning architectures pose new serious security threats, hindering the use of these tools in security-oriented applications, and, among them, multimedia forensics. The analysis of the security of machine learning-based techniques in the presence of an adversary attempting to impede the forensic analysis, and the development of new solutions capable to improve the security of such techniques is then of primary importance, and, recently, has marked the birth of a new discipline, named Adversarial Machine Learning. By focusing on Image Forensics and ...

In this doctoral thesis several scale-free texture segmentation procedures based on two fractal attributes, the Hölder exponent, measuring the local regularity of a texture, and local variance, are proposed.A piecewise homogeneous fractal texture model is built, along with a synthesis procedure, providing images composed of the aggregation of fractal texture patches with known attributes and segmentation. This synthesis procedure is used to evaluate the proposed methods performance.A first method, based on the Total Variation regularization of a noisy estimate of local regularity, is illustrated and refined thanks to a post-processing step consisting in an iterative thresholding and resulting in a segmentation.After evidencing the limitations of this first approach, deux segmentation methods, with either "free" or "co-located" contours, are built, taking in account jointly the local regularity and the local variance.These two procedures are formulated as convex nonsmooth functional minimization problems.We ...

In this thesis, we present a convex optimization approach to address three problems arising in multicomponent image recovery, supervised classification, and image forgery detection. The common thread among these problems is the presence of nonlinear convex constraints difficult to handle with state-of-the-art methods. Therefore, we present a novel splitting technique to simplify the management of such constraints. Relying on this approach, we also propose some contributions that are tailored to the aforementioned applications. The first part of the thesis presents the epigraphical splitting of nonlinear convex constraints. The principle is to decompose the sublevel set of a block-separable function into a collection of epigraphs. So doing, we reduce the complexity of optimization algorithms when the above constraint involves the sum of absolute values, distance functions to a convex set, Euclidean norms, infinity norms, or max functions. We demonstrate through numerical ...

Advances in compression techniques, decreasing cost of storage, and high-speed transmission have facilitated the way videos are created, stored and distributed. As a consequence, videos are now being used in many applications areas. The increase in the amount of video data deployed and used in today's applications reveals not only the importance as multimedia data type, but also led to the requirement of efficient management of video data. This management paved the way for new research areas, such as indexing and retrieval of video with respect to their spatio-temporal, visual and semantic contents. This thesis presents work towards a unified framework for semi-automated video indexing and interactive retrieval. To create an efficient index, a set of representative key frames are selected which capture and encapsulate the entire video content. This is achieved by, firstly, segmenting the video into its constituent ...

The present doctoral thesis aims towards the development of new long-term, multi-channel, audio-visual processing techniques for the analysis of bioacoustics phenomena. The effort is focused on the study of the physiology of the gastrointestinal system, aiming at the support of medical research for the discovery of gastrointestinal motility patterns and the diagnosis of functional disorders. The term "processing" in this case is quite broad, incorporating the procedures of signal processing, content description, manipulation and analysis, that are applied to all the recorded bioacoustics signals, the auxiliary audio-visual surveillance information (for the monitoring of experiments and the subjects' status), and the extracted audio-video sequences describing the abdominal sound-field alterations. The thesis outline is as follows. The main objective of the thesis, which is the technological support of medical research, is presented in the first chapter. A quick problem definition is initially ...

The interest for the intelligent vehicle field has been increased during the last years, must probably due to an important number of road accidents. Many accidents could be avoided if a device attached to the vehicle would assist the driver with some warnings when dangerous situations are about to appear. In recent years, leading car developers have recorded significant efforts and support research works regarding the intelligent vehicle field where they propose solutions for the existing problems, especially in the vision domain. Road detection and following, pedestrian or vehicle detection, recognition and tracking, night vision, among others are examples of applications which have been developed and improved recently. Still, a lot of challenges and unsolved problems remain in the intelligent vehicle domain. Our purpose in this thesis is to design an Obstacle Recognition system for improving the road security by ...

Voice disorders need to be better understood because they may lead to reduced job chances and social isolation. Correct treatment indication and treatment effect measurements are needed to tackle these problems. They must rely on robust outcome measures for clinical intervention studies. Diplophonia is a severe and often misunderstood sign of voice disorders. Depending on its underlying etiology, diplophonic patients typically receive treatment such as logopedic therapy or phonosurgery. In the current clinical practice diplophonia is determined auditively by the medical doctor, which is problematic from the viewpoints of evidence-based medicine and scientific methodology. The aim of this thesis is to work towards objective (i.e., automatic) detection of diplophonia. A database of 40 euphonic, 40 diplophonic and 40 dysphonic subjects has been acquired. The collected material consists of laryngeal high-speed videos and simultaneous high-quality audio recordings. All material has been ...

This thesis introduces new learning algorithms for Radial Basis Function (RBF) networks. RBF networks is a feed-forward two-layer neural network used for functional approximation or pattern classification applications. The proposed training algorithms are based on robust statistics. Their theoretical performance has been assessed and compared with that of classical algorithms for training RBF networks. The applications of RBF networks described in this thesis consist of simultaneously modeling moving object segmentation and optical flow estimation in image sequences and 3-D image modeling and segmentation. A Bayesian classifier model is used for the representation of the image sequence and 3-D images. This employs an energy based description of the probability functions involved. The energy functions are represented by RBF networks whose inputs are various features drawn from the images and whose outputs are objects. The hidden units embed kernel functions. Each kernel ...

Magnetic Resonance Imaging (MRI) constitutes a non-invasive medical imaging technique that allows the exploration of the inner anatomy, tissues, and physiological processes of the body. Among the different MRI applications, functional Magnetic Resonance Imaging (fMRI) has slowly become an essential tool for investigating the brain behavior and, nowadays, it plays a fundamental role in clinical and neurophysiological research. Due to its particular nature, specialized signal processing techniques are required in order to analyze the fMRI data properly. Among the various related techniques that have been developed over the years, the General Linear Model (GLM) is one of the most widely used approaches, and it usually appears as a default in many specialized software toolboxes for fMRI. On the other end, Blind Source Separation (BSS) methods constitute the most common alternative to GLM, especially when no prior information regarding the brain ...

This doctoral thesis focuses on the development of algorithms of speaker characterisation by voice. Namely, characterisation of speaker’s identity, and the emotional state detectable in his voice while using the application of state-of-the art classifier algorithm Support Vector Machine (SVM) will be discussed. The first part deals with the state of the art SVM classifier utilised for classification experiments where we search for more sophisticated form of SVM model parameters selection. Also, we successfully apply optimization methods (PSO and GA algorithm) on two classification problems. The second part of this thesis deal with emotion recognition in continuous/dimensional space.