Alzheimer’s disease (AD) is a neurodegenerative terminal disorder that accounts for nearly 70% of dementia cases worldwide. Global dementia incidence is projected to 75 million cases by 2030, with the majority of the affected individuals coming from low- and medium- income countries. Although there is no cure for AD, early diagnosis can improve the quality of life of AD patients and their caregivers. Currently, AD diagnosis is carried out using mental status examinations, expensive neuroimaging scans, and invasive laboratory tests, all of which render the diagnosis time-consuming and costly. Notwithstanding, over the last decade electroencephalography (EEG), specifically resting-state EEG (rsEEG), has emerged as an alternative technique for AD diagnosis with accuracies inline with those obtained with more expensive neuroimaging tools, such as magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET). However the use of rsEEG for ...

This work has, as its objective, the development of non-invasive and low-cost systems for monitoring and automatic diagnosing specific neonatal diseases by means of the analysis of suitable video signals. We focus on monitoring infants potentially at risk of diseases characterized by the presence or absence of rhythmic movements of one or more body parts. Seizures and respiratory diseases are specifically considered, but the approach is general. Seizures are defined as sudden neurological and behavioural alterations. They are age-dependent phenomena and the most common sign of central nervous system dysfunction. Neonatal seizures have onset within the 28th day of life in newborns at term and within the 44th week of conceptional age in preterm infants. Their main causes are hypoxic-ischaemic encephalopathy, intracranial haemorrhage, and sepsis. Studies indicate an incidence rate of neonatal seizures of 2‰ live births, 11‰ for preterm ...

Localizing the bioelectric phenomena originating from the cerebral cortex and evoked by auditory and somatosensory stimuli are clear objectives to both understand how the brain works and to recognize different pathologies. Diseases such as Parkinson's, Alzheimer's, schizophrenia and epilepsy are intensively studied to find a cure or accurate diagnosis. Epilepsy is considered the disease with major prevalence within disorders with neurological origin. The recurrent and sudden incidence of seizures can lead to dangerous and possibly life-threatening situations. Since disturbance of consciousness and sudden loss of motor control often occur without any warning, the ability to predict epileptic seizures would reduce patients' anxiety, thus considerably improving quality of life and safety. The common procedure for epilepsy seizure detection is based on brain activity monitorization via electroencephalogram (EEG) data. This process consumes a lot of time, especially in the case of long ...

Identifying the target speaker in hearing aid applications is an essential ingredient to improve speech intelligibility. Although several speech enhancement algorithms are available to reduce background noise or to perform source separation in multi-speaker scenarios, their performance depends on correctly identifying the target speaker to be enhanced. Recent advances in electroencephalography (EEG) have shown that it is possible to identify the target speaker which the listener is attending to using single-trial EEG-based auditory attention decoding (AAD) methods. However, in realistic acoustic environments the AAD performance is influenced by undesired disturbances such as interfering speakers, noise and reverberation. In addition, it is important for real-world hearing aid applications to close the AAD loop by presenting on-line auditory feedback. This thesis deals with the problem of identifying and enhancing the target speaker in realistic acoustic environments based on decoding the auditory attention ...

Electroencephalography (EEG) is a non-invasive neurorecording technique, which has the potential to be used for 24/7 neuromonitoring in daily life, e.g., in the context of neural prostheses, brain-computer interfaces, or for improved diagnosis of brain disorders. Although existing mobile wireless EEG headsets are a useful tool for short-term experiments, they are still too heavy, bulky and obtrusive, for long-term EEG-monitoring in daily life. However, we are now witnessing a wave of new miniature EEG sensor devices containing small electrodes embedded in them, which we refer to as Mini-EEGs. Mini-EEGs ideally consist of a wireless node with a small scalp area footprint, in which the electrodes, amplifier and wireless radio are embedded. However, due to their miniaturization, these mini-EEGs have the drawback that only a few EEG channels can be recorded within a small area. The latter also implies that the ...

Objective diagnosis and therapy evaluation are still challenging tasks for many neurological disorders. This is highly related to the diversity of cases and the variety of treatment modalities available. Especially in the case of epilepsy, which is a complex disorder not well-explained at the biochemical and physiological levels, there is the need for investigations for novel features, which can be extracted and quantified from electrophysiological signals in clinical practice. Neurotherapy is a complementary treatment applied in various disorders of the central nervous system, including epilepsy. The method is subsumed under behavioral medicine and is considered an operant conditioning in psychological terms. Although the application areas of this promising unconventional approach are rapidly increasing, the method is strongly debated, since the neurophysiological underpinnings of the process are not yet well understood. Therefore, verification of the efficacy of the treatment is one ...

Biometric systems consist in the combination of devices, algorithms, and procedures used to recognize the individuals based on the characteristics, physical or behavioral, of their persons. These characteristics are called biometric traits. Nowadays, biometric technologies are becoming more and more widespread, and many people use biometric systems daily. However, in some cases the procedures used for the collection of the biometric traits need the cooperation of the user, controlled environments, illuminations perceived as unpleasant, too strong, or harmful, or the contact of the body with a sensor. For these reasons, techniques for the contactless and less-constrained biometric recognition are being researched, in order to increase the usability and social acceptance of biometric systems, and increase the fields of application of biometric technologies. In this context, the palmprint is a biometric trait whose acquisition is generally well accepted by the users. ...

Understanding the cognitive processes that are going on in the human brain, requires the combination of several types of observations. For this reason, since several years, neuroscience research started to focus on multimodal approaches. One such multimodal approach is the combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). The non-invasive character of these two modalities makes their combination not only harmless and painless, but also especially suited for widespread research in both clinical and experimental applications. Moreover, the complementarity between the high temporal resolution of the EEG and the high spatial resolution of the fMRI, allows obtaining a more complete picture of the processes under study. However, the combination of EEG and fMRI is challenging, not only on the level of the data acquisition, but also when it comes to extracting the activity of interest and interpreting the ...

Every year, an estimated 15 million babies are born preterm, that is, before 37 weeks of gestation. This number is rising in all countries and currently represents more than 1 in 10 babies, affecting families all over the world. During the last decades, the survival rate of prematurely born neonates has steadily increased, mainly as a result of medical and technical progress in neonatal intensive care. The very preterm infants, which represent up to 10% of the preterm infants in the EU, remain at risk for adverse outcome and neurodevelopmental disability. These maladaptive outcomes have a severe effect on the children’s quality of life and a huge economic impact on society. In order to reduce this burden and improve neonatal care in general, appropriate tools need to be developed to identify the neonates with a higher risk of adverse outcomes. ...

Current Human-Machine Interfaces (HMI) lack of “emotional intelligence”, i.e. they are not able to identify human emotional states and take this information into account to decide on the proper actions to execute. The goal of affective computing is to fill this lack by detecting emotional cues occurring during Human-Computer Interaction (HCI) and synthesizing emotional responses. In the last decades, most of the studies on emotion assessment have focused on the analysis of facial expressions and speech to determine the emotional state of a person. Physiological activity also includes emotional information that can be used for emotion assessment but has received less attention despite of its advantages (for instance it can be less easily faked than facial expressions). This thesis reports on the use of two types of physiological activities to assess emotions in the context of affective computing: the activity ...

One in five experiences hearing loss. The World Health Organization estimates that this number will increase to one in four in 2050. Luckily, effective hearing devices such as hearing aids and cochlear implants exist with advanced speaker enhancement algorithms that can significantly improve the quality of life of people suffering from hearing loss. State-of-the-art hearing devices, however, underperform in a so-called `cocktail party' scenario, when multiple persons are talking simultaneously (such as at a family dinner or reception). In such a situation, the hearing device does not know which speaker the user intends to attend to and thus which speaker to enhance and which other ones to suppress. Therefore, a new problem arises in cocktail party problems: determining which speaker a user is attending to, referred to as the auditory attention decoding (AAD) problem. The problem of selecting the attended ...

Around 10 percent of all human births is premature, which means that annually about 15 million babies are born before 37 completed weeks of gestation. About one third of the admissions to the Neonatal Intensive Care Unit (NICU) consists of this patient group. Due to complications, 1 million babies die from premature delivery, and it is therefore the most important cause of neonatal death. In general, premature and immature babies have a high risk for neurological abnormalities by maturation in extra-uterine life. Even though improved health care has increased the survival changes of these neonates, they are sensitive to brain damage and consequently, neurocognitive disabilities. Nowadays, critical information about the brain development can be extracted from the electroencephalography (EEG). Clinical experts visually assess evolving EEG characteristics over both short and long periods to evaluate maturation of patients at risk and, ...

Brain disorders represent a significant health challenge. It is estimated that approximately 165 million people suffer from a brain disorder in Europe, while 1 in 3 people will experience such a disorder during their lifetime. Some types of the brain disorders are the following: Alzheimer’s disease, dementias, epilepsy, Parkinson’s disease, Mental disorders, and more. These disorders affect the way people think, feel, or perform daily activities. However, if these disorders are diagnosed early and the person receives suitable medication, their progression may be delayed. For this reason, early diagnosis is crucial. Artificial Intelligence (AI) holds the promise of transforming how we tackle societal issues and enhancing the welfare of both individuals and communities. “AI for Social Good”, also known as “AI for Social Impact” is a new research field aiming to tackle some of the most important social, environmental, and ...

This thesis focuses on the design of various automatic signal processing algorithms to extract information from physiological signals of preterm infants. Overall, the aim was to improve the neurodevelopmental outcome of the neonate. More specifically, three main research objectives were carried out. The first objective was to describe the maturation of neonates during their stay in the neonatal intensive care unit. The second objective was to assess the stress and pain in premature infants and their impact on the development of neonates. The third objective was to predict developmental disabilities, such as autism. The first part of this thesis presents an extensive overview of various developmental models to describe the maturation of premature infants. Three main strategies were proposed. The first strategy proposed an investigation of EEG connectivity networks. A variety of functional and effective connectivity methods were combined with ...

In the world of Information and communications technology (ICT), strategies for innovation and development are increasingly focusing on applications that require spatial representation and real-time interaction with and within 3D-media environments. One of the major challenges that such applications have to address is user-centricity, reflecting e.g. on developing complexity-hiding services so that people can personalize their own delivery of services. In these terms, multimodal interfaces represent a key factor for enabling an inclusive use of new technologies by everyone. In order to achieve this, multimodal realistic models that describe our environment are needed, and in particular models that accurately describe the acoustics of the environment and communication through the auditory modality are required. Examples of currently active research directions and application areas include 3DTV and future internet, 3D visual-sound scene coding, transmission and reconstruction and teleconferencing systems, to name but ...