Work-related musculoskeletal disorders are a growing problem in todays society. These musculoskeletal disorders are caused by, amongst others, repetitive movements and mental stress. Stress is defined as the mismatch between a perceived demand and the perceived capacities to meet this demand. Although stress has a subjective origin, several physiological manifestations (e.g. cardiovascular and muscular) occur during periods of perceived stress. New insight and algorithms to extract information, related to stress are beneficial. Therefore, two series of stress experiments are executed in a laboratory environment, where subjects underwent different tasks inducing physical strain, mental stress and a combination of both. In this manuscript, new and modified algorithms for electromyography signals are presented that improve the individual analysis of electromyography signals. A first algorithm removes the interference of the electrical activity of the heart on singlechannel electromyography measurements. This interference signal is ...

This dissertation develops false discovery rate (FDR) controlling machine learning algorithms for large-scale high-dimensional data. Ensuring the reproducibility of discoveries based on high-dimensional data is pivotal in numerous applications. The developed algorithms perform fast variable selection tasks in large-scale high-dimensional settings where the number of variables may be much larger than the number of samples. This includes large-scale data with up to millions of variables such as genome-wide association studies (GWAS). Theoretical finite sample FDR-control guarantees based on martingale theory have been established proving the trustworthiness of the developed methods. The practical open-source R software packages TRexSelector and tlars, which implement the proposed algorithms, have been published on the Comprehensive R Archive Network (CRAN). Extensive numerical experiments and real-world problems in biomedical and financial engineering demonstrate the performance in challenging use-cases. The first three main parts of this dissertation present ...

The ever-increasing growth of the wireless application and services affirms the importance of the effective usage of the limited radio spectrum. Existing spectrum management policies have led to significant spectrum under-utilization. Recent measurements showed that large range of the spectrum is sparsely used in both temporal and spatial manner. This conflict between the inefficient usage of the spectrum and the continuous evolution in the wireless communication calls upon the development of more flexible management policies. Cognitive radio (CR) with the dynamic spectrum access (DSA) is considered to be a key technology in making the best solution of this conflict by allowing a group of secondary users (SUs) to share the radio spectrum originally allocated to the primary user (PUs). The operation of CR should not negatively alter the performance of the PUs. Therefore, the interference control along with the highly ...

This PhD thesis addresses the problem of measuring blood glucose from a photometric measurement setup that requires blood samples in the nano litre-range, which is several orders of magnitude less than the state of the art. The chemical reaction between the blood sample and the reagent in this setup is observed by a camera over time. Notably, the presented framework can be generalised to any image-based photometric measurement scheme in the context of modern biosensors. In this thesis a framework is developed to measure the glucose concentration from the raw images obtained by the camera. Initially, a pre-processing scheme is presented to enhance the raw images. Moreover, a reaction onset detection algorithm is developed. This eliminates unnecessary computation during the constant phase of the chemical reaction. To detect faulty glucose measurements, methods of texture analysis are identified and employed in ...

Every year, an estimated 15 million babies are born preterm, that is, before 37 weeks of gestation. This number is rising in all countries and currently represents more than 1 in 10 babies, affecting families all over the world. During the last decades, the survival rate of prematurely born neonates has steadily increased, mainly as a result of medical and technical progress in neonatal intensive care. The very preterm infants, which represent up to 10% of the preterm infants in the EU, remain at risk for adverse outcome and neurodevelopmental disability. These maladaptive outcomes have a severe effect on the children’s quality of life and a huge economic impact on society. In order to reduce this burden and improve neonatal care in general, appropriate tools need to be developed to identify the neonates with a higher risk of adverse outcomes. ...

It takes more time to think of a silent scene, action or event than finding one that emanates sound. Not only speaking or playing music but almost everything that happens is accompanied with or results in one or more sounds mixed together. This makes acoustic event detection (AED) one of the most researched topics in audio signal processing nowadays and it will probably not see a decline anywhere in the near future. This is due to the thirst for understanding and digitally abstracting more and more events in life via the enormous amount of recorded audio through thousands of applications in our daily routine. But it is also a result of two intrinsic properties of audio: it doesn’t need a direct sight to be perceived and is less intrusive to record when compared to image or video. Many applications such ...

Never before has speech been captured as often by electronic devices equipped with one or multiple microphones, serving a variety of applications. It is the key aspect in digital telephony, hearing devices, and voice-driven human-to-machine interaction. When speech is recorded, the microphones also capture a variety of further, undesired sound components due to adverse acoustic conditions. Interfering speech, background noise and reverberation, i.e. the persistence of sound in a room after excitation caused by a multitude of reflections on the room enclosure, are detrimental to the quality and intelligibility of target speech as well as the performance of automatic speech recognition. Hence, speech enhancement aiming at estimating the early target-speech component, which contains the direct component and early reflections, is crucial to nearly all speech-related applications presently available. In this thesis, we compare, propose and evaluate existing and novel approaches ...

The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorders. One such brain disorder is schizophrenia, a neurodevelopmental disease characterized by abnormal perception of reality that manifests in symptoms like hallucinations or delusions. Even though the brain is known to be affected in schizophrenia, the exact pathophysiology underlying its developmental course is still mostly unknown. In this thesis, we develop and apply methods to look into ongoing brain function measured through magnetic resonance imaging (MRI) and evaluate the potential of these approaches for improving our understanding of psychosis vulnerability and schizophrenia. We focus on patients with chromosome 22q11.2 deletion syndrome (22q11DS), a genetic disorder that comes with a 30fold increased risk for ...

The recent announcement by the LIGO and Virgo Collaborations of the direct detection of gravitational waves started the era of gravitational wave astrophysics. Up to now there have been five confirmed detections (GW150914, GW151226, GW170104, GW170814 and GW170817). Each of the GW events detected so far, shed light on multiple aspects of gravity. The first four events were due to the coalescence of a binary black hole system. August 17th 2017 marked the beginning of the so-called Multi-Messenger astronomy: the binary neutron star merger GW170817 has been observed almost simultaneously by LIGO and Virgo interferometers and several telescopes in space and on Earth, which detected the electromagnetic counterpart of this event (first as a short gamma-ray burst, GRB 170817A, and then in the visible, infra-red and X-ray bands). These last two years of great scientific discoveries would not have been ...

Cardiovascular diseases are a growing problem in today’s society. The World Health Organization (WHO) reported that these diseases make up about 30% of total global deaths and that heart diseases have no geographic, gender or socioeconomic boundaries. Therefore, detecting cardiac irregularities early-stage and a correct treatment are very important. However, this requires a good physiological understanding of the cardiovascular system. The heart is stimulated electrically by the brain via the autonomic nervous system, where sympathetic and vagal pathways are always interacting and modulating heart rate. Continuous monitoring of the heart activity is obtained by means of an ElectroCardioGram (ECG). Studying the fluctuations of heart beat intervals over time reveals a lot of information and is called heart rate variability (HRV) analysis. A reduction of HRV has been reported in several cardiological and noncardiological diseases. Moreover, HRV also has a prognostic ...

This doctorate thesis focuses on sparse regression, a statistical modeling tool for selecting valuable predictors in underdetermined linear models. By imposing different constraints on the structure of the variable vector in the regression problem, one obtains estimates which have sparse supports, i.e., where only a few of the elements in the response variable have non-zero values. The thesis collects six papers which, to a varying extent, deals with the applications, implementations, modifications, translations, and other analysis of such problems. Sparse regression is often used to approximate additive models with intricate, non-linear, non-smooth or otherwise problematic functions, by creating an underdetermined model consisting of candidate values for these functions, and linear response variables which selects among the candidates. Sparse regression is therefore a widely used tool in applications such as, e.g., image processing, audio processing, seismological and biomedical modeling, but is ...

The problem of segregating a sound source of interest from an acoustic background has been extensively studied due to applications in hearing prostheses, robust speech/speaker recognition and audio information retrieval. Computational auditory scene analysis (CASA) approaches the segregation problem by utilizing grouping cues involved in the perceptual organization of sound by human listeners. Binaural processing, where input signals resemble those that enter the two ears, is of particular interest in the CASA field. The dominant approach to binaural segregation has been to derive spatially selective filters in order to enhance the signal in a direction of interest. As such, the problems of sound localization and sound segregation are closely tied. While spatial filtering has been widely utilized, substantial performance degradation is incurred in reverberant environments and more fundamentally, segregation cannot be performed without sufficient spatial separation between sources. This dissertation ...

The increasing number of simultaneous input and output channels utilized in immersive audio configurations primarily in broadcasting applications has renewed industrial requirements for efficient audio coding schemes with low bit-rate and complexity. This thesis presents a comprehensive review and extension of conventional approaches for perceptual coding of arbitrary multichannel audio signals. Particular emphasis is given to use cases ranging from two-channel stereophonic to six-channel 5.1-surround setups with or without the application-specific constraint of low algorithmic coding latency. Conventional perceptual audio codecs share six common algorithmic components, all of which are examined extensively in this thesis. The first is a signal-adaptive filterbank, constructed using instances of the real-valued modified discrete cosine transform (MDCT), to obtain spectral representations of successive portions of the incoming discrete time signal. Within this MDCT spectral domain, various intra- and inter-channel optimizations, most of which are of ...

This work has, as its objective, the development of non-invasive and low-cost systems for monitoring and automatic diagnosing specific neonatal diseases by means of the analysis of suitable video signals. We focus on monitoring infants potentially at risk of diseases characterized by the presence or absence of rhythmic movements of one or more body parts. Seizures and respiratory diseases are specifically considered, but the approach is general. Seizures are defined as sudden neurological and behavioural alterations. They are age-dependent phenomena and the most common sign of central nervous system dysfunction. Neonatal seizures have onset within the 28th day of life in newborns at term and within the 44th week of conceptional age in preterm infants. Their main causes are hypoxic-ischaemic encephalopathy, intracranial haemorrhage, and sepsis. Studies indicate an incidence rate of neonatal seizures of 2‰ live births, 11‰ for preterm ...

The subject of this PhD thesis is the efficient and robust processing and analysis of the audio recordings that are derived from a call center. The thesis is comprised of two parts. The first part is dedicated to dialogue/non-dialogue detection and to speaker segmentation. The systems that are developed are prerequisite for detecting (i) the audio segments that actually contain a dialogue between the system and the call center customer and (ii) the change points between the system and the customer. This way the volume of the audio recordings that need to be processed is significantly reduced, while the system is automated. To detect the presence of a dialogue several systems are developed. This is the first effort found in the international literature that the audio channel is exclusively exploited. Also, it is the first time that the speaker utterance ...