Localizing the bioelectric phenomena originating from the cerebral cortex and evoked by auditory and somatosensory stimuli are clear objectives to both understand how the brain works and to recognize different pathologies. Diseases such as Parkinson's, Alzheimer's, schizophrenia and epilepsy are intensively studied to find a cure or accurate diagnosis. Epilepsy is considered the disease with major prevalence within disorders with neurological origin. The recurrent and sudden incidence of seizures can lead to dangerous and possibly life-threatening situations. Since disturbance of consciousness and sudden loss of motor control often occur without any warning, the ability to predict epileptic seizures would reduce patients' anxiety, thus considerably improving quality of life and safety. The common procedure for epilepsy seizure detection is based on brain activity monitorization via electroencephalogram (EEG) data. This process consumes a lot of time, especially in the case of long ...

This work has, as its objective, the development of non-invasive and low-cost systems for monitoring and automatic diagnosing specific neonatal diseases by means of the analysis of suitable video signals. We focus on monitoring infants potentially at risk of diseases characterized by the presence or absence of rhythmic movements of one or more body parts. Seizures and respiratory diseases are specifically considered, but the approach is general. Seizures are defined as sudden neurological and behavioural alterations. They are age-dependent phenomena and the most common sign of central nervous system dysfunction. Neonatal seizures have onset within the 28th day of life in newborns at term and within the 44th week of conceptional age in preterm infants. Their main causes are hypoxic-ischaemic encephalopathy, intracranial haemorrhage, and sepsis. Studies indicate an incidence rate of neonatal seizures of 2‰ live births, 11‰ for preterm ...

This dissertation is concerned with the application of the theory of rational functions in signal processing. The PhD thesis summarizes the corresponding results of the author’s research. Since the systems of rational functions are defined by the collection of inverse poles with multiplicities, the following parameters should be determined: the number, the positions and the multiplicities of the inverse poles. Therefore, we develop the hyperbolic variant of the so-called Nelder–Mead and the particle swarm optimization algorithm. In addition, the latter one is integrated into a more general multi-dimensional framework. Furthermore, we perform a detailed stability and error analysis of these methods. We propose an electrocardiogram signal generator based on spline interpolation. It turns to be an efficient tool for testing and evaluating signal models, filtering techniques, etc. In this thesis, the synthesized heartbeats are used to test the diagnostic distortion ...

Brain function requires a continuous flow of oxygen and glucose. An insufficient supply for a few minutes during the first period of life may have severe consequences or even result in death. This happens in one to six infants per 1000 live term births. Therefore, there is a high need for a method which can enable bedside brain monitoring to identify those neonates at risk and be able to start the treatment in time. The most important currently available technology to continuously monitor brain function is electroEncephaloGraphy (or EEG). Unfortunately, visual EEG analysis requires particular skills which are not always present round the clock in the Neonatal Intensive Care Unit (NICU). Even if those skills are available it is laborsome to manually analyse many hours of EEG. The lack of time and skill are the main reasons why EEG is ...

In this dissertation, the traditional Gabor represantation with sinusoidal basis functions, which is widely used in the time-frequency analysis of non-stationary signals, is extended to the Fractional Gabor expansion with fractionally modulated basis functions. The completeness and biorthoganility conditions of the analysis and synthesis basis sets of the expansion are derived. Then, a discrete fractional Gabor expansion, that can be used to analyze discrete-time signals, is obtained by sampling the continuous-time represantation. By deriving the completeness and biorthoganility conditions, the discrete fractional Gabor expansion can be implemented on a computer to analyze discrete-time signals. Furthermore, to increase the time-frequency resolution of the signal represantation, time-scaled version of a mother window are used to obtain Multi-window fractional Gabor expansion. Finally an evolutionary spectral analysis approach is given for the time-varying spectral analysis of non-stationary signals. The connection between spectral representation and ...

Epilepsy is a neurological condition that manifests in epileptic seizures as a result of an abnormal, synchronous activity of a large group of neurons. Depending on the affected brain regions, seizures produce various severe clinical symptoms. Epilepsy cannot be cured and in many cases is not controlled by medication either. Surgical resection of the region responsible for generating the epileptic seizures might offer remedy for these patients. Electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) measure the changes of brain activity in time over different locations of the brain. As such, they provide valuable information on the nature, the timing and the spatial origin of the epileptic activity. Unfortunately, both techniques record activity of different brain and artefact sources as well. Hence, EEG and fMRI signals are characterised by low signal to noise ratio. Data quality and the vast amount ...

Epilepsy is one of the most common neurological disorders, which affects almost 1% of the population worldwide. Anti-epileptic drugs provide adequate treatment for about 70% of epilepsy patients. The remaining 30% of the patients continue to have seizures, which drastically affects their quality of life. In order to obtain efficacy measures of therapeutic interventions for these patients, an objective way to count and document seizures is needed. However, in an outpatient setting, one of the major problems is that seizure diaries kept by patients are unreliable. Automated seizure detection systems could help to objectively quantify seizures. Those detection systems are typically based on full scalp Electroencephalography (EEG). In an outpatient setting, full scalp EEG is of limited use because patients will not tolerate wearing a full EEG cap for long time periods during daily life. There is a need for ...

The improvement of speech intelligibility is a traditional problem which still remains open and unsolved. The recent boom of applications such as hands-free communi- cations or automatic speech recognition systems and the ever-increasing demands of the hearing-impaired community have given a definitive impulse to the research in this area. This PhD thesis is focused on speech enhancement for audiological applications. Most of the research conducted in this thesis has been focused on the improvement of speech intelligibility in hearing aids, considering the variety of restrictions and limitations imposed by this type of devices. The combination of source separation techniques and spatial filtering with machine learning and evolutionary computation has originated novel and interesting algorithms which are included in this thesis. The thesis is divided in two main parts. The first one contains a preliminary study of the problem and a ...

This dissertation focuses on the development of novel parametric spatial audio techniques using compact microphone arrays. Compact arrays are of special interest since they can be adapted to fit in portable devices, opening the possibility of exploiting the potential of immersive spatial audio algorithms in our daily lives. The techniques developed in this thesis consider the use of signal processing algorithms adapted for human listeners, thus exploiting the capabilities and limitations of human spatial hearing. The findings of this research are in the following three areas of spatial audio processing: directional filtering, spatial audio reproduction, and direction of arrival estimation. In directional filtering, two novel algorithms have been developed based on the cross-pattern coherence (CroPaC). The method essentially exploits the directional response of two different types of beamformers by using their cross-spectrum to estimate a soft masker. The soft masker ...

Epilepsy is one of the most common neurological diseases that manifests in repetitive epileptic seizures as a result of an abnormal, synchronous activity of a large group of neurons. Depending on the affected brain regions, seizures produce various severe clinical symptoms. There is no cure for epilepsy and sometimes even medication and other therapies, like surgery, vagus nerve stimulation or ketogenic diet, do not control the number of seizures. In that case, long-term (home) monitoring and automatic seizure detection would enable the tracking of the evolution of the disease and improve objective insight in any responses to medical interventions or changes in medical treatment. Especially during the night, supervision is reduced; hence a large number of seizures is missed. In addition, an alarm should be integrated into the automated seizure detection algorithm for severe seizures in order to help the ...

Worldwide approximately 11% of the babies are born before 37 weeks of gestation. The survival rates of these prematurely born infants have steadily increased during the last decades as a result of the technical and medical progress in the neonatal intensive care units (NICUs). The focus of the NICUs has therefore gradually evolved from increasing life chances to improving quality of life. In this respect, promoting and supporting optimal brain development is crucial. Because these neonates are born during a period of rapid growth and development of the brain, they are susceptible to brain damage and therefore vulnerable to adverse neurodevelopmental outcome. In order to identify patients at risk of long-term disabilities, close monitoring of the neurological function during the first critical weeks is a primary concern in the current NICUs. Electroencephalography (EEG) is a valuable tool for continuous noninvasive ...

The overriding aim of this thesis is to investigate the benefits of focusing time-frequency analysis on particular regions of the time-frequency plane. The thesis examines aspects of such a regionalisation in the analysis of both deterministic signals and stochastic processes. The majority of deterministic energetic time-frequency representations are non-parametric indicating the distribution of the energy of a signal in the time-frequency plane but providing no further information about the time-frequency structure. This thesis develops a semi-parametric time-frequency model to simultaneously describe the time-frequency energetic structure of a signal and provide an indication of its time-frequency complexity. The model aims to identify ‘timefrequency components’ within the signal to indicate how their energy is distributed in the time-frequency plane and thereby to probabilistically associate every location in the plane with each identified component. The thesis investigates a number of applications of the ...

The increasing number of simultaneous input and output channels utilized in immersive audio configurations primarily in broadcasting applications has renewed industrial requirements for efficient audio coding schemes with low bit-rate and complexity. This thesis presents a comprehensive review and extension of conventional approaches for perceptual coding of arbitrary multichannel audio signals. Particular emphasis is given to use cases ranging from two-channel stereophonic to six-channel 5.1-surround setups with or without the application-specific constraint of low algorithmic coding latency. Conventional perceptual audio codecs share six common algorithmic components, all of which are examined extensively in this thesis. The first is a signal-adaptive filterbank, constructed using instances of the real-valued modified discrete cosine transform (MDCT), to obtain spectral representations of successive portions of the incoming discrete time signal. Within this MDCT spectral domain, various intra- and inter-channel optimizations, most of which are of ...

Localization, separation and tracking of acoustic sources are ancient challenges that lots of animals and human beings are doing intuitively and sometimes with an impressive accuracy. Artificial methods have been developed for various applications and conditions. The majority of those methods are centralized, meaning that all signals are processed together to produce the estimation results. The concept of distributed sensor networks is becoming more realistic as technology advances in the fields of nano-technology, micro electro-mechanic systems (MEMS) and communication. A distributed sensor network comprises scattered nodes which are autonomous, self-powered modules consisting of sensors, actuators and communication capabilities. A variety of layout and connectivity graphs are usually used. Distributed sensor networks have a broad range of applications, which can be categorized in ecology, military, environment monitoring, medical, security and surveillance. In this dissertation we develop algorithms for distributed sensor networks ...

The purpose of this thesis is to describe novel signal processing methodologies and analog integrated circuit techniques for low-power biomedical systems. Physiological signals, such as the electrocardiogram (ECG), the electroencephalogram (EEG) and the electromyogram (EMG) are mostly non-stationary. The main difficulty in dealing with biomedical signal processing is that the information of interest is often a combination of features that are well localized temporally (e.g., spikes) and others that are more diffuse (e.g., small oscillations). This requires the use of analysis methods sufficiently versatile to handle events that can be at opposite extremes in terms of their time-frequency localization. Wavelet Transform (WT) has been extensively used in biomedical signal processing, mainly due to the versatility of the wavelet tools. The WT has been shown to be a very efficient tool for local analysis of nonstationary and fast transient signals due ...