This thesis focuses on wearables for health status monitoring, covering applications aimed at emergency solutions to the COVID-19 pandemic and aging society. The methods of ambient assisted living (AAL) are presented for the neurodegenerative disease Parkinson’s disease (PD), facilitating ’aging in place’ thanks to machine learning and around wearables - solutions of mHealth. Furthermore, the approaches using machine learning and wearables are discussed for early-stage COVID-19 detection, with encouraging accuracy. Firstly, a publicly available dataset containing COVID-19, influenza, and healthy control data was reused for research purposes. The solution presented in this thesis is considering the classification problem and outperformed the state-of-the-art methods, whereas the original paper introduced just anomaly detection and not shown the specificity of the created models. The proposed model in the thesis for early detection of COVID-19 achieved 78 % for the k-NN classifier. Moreover, a ...

Voice pathology is a diverse field that includes various disorders affecting vocal quality and production. Using audio machine learning for voice pathology classification represents an innovative approach to diagnosing a wide range of voice disorders. Despite extensive research in this area, there remains a significant gap in the development of classifiers and their ability to adapt and generalize effectively. This thesis aims to address this gap by contributing new insights and methods. This research provides a comprehensive exploration of automatic voice pathology classification, focusing on challenges such as data limitations and the potential of integrating multiple modalities to enhance diagnostic accuracy and adaptability. To achieve generalization capabilities and enhance the flexibility of the classifier across diverse types of voice disorders, this research explores various datasets and pathology types comprehensively. It covers a broad range of voice disorders, including functional dysphonia, ...

Obstructive sleep apnea (OSA) is the most prevalent sleep related breathing disorder, nevertheless subjects suffering from it often remain undiagnosed due to the cumbersome diagnosis procedure. Moreover, the prevalence of OSA is increasing and a better phenotyping of patients is needed in order to prioritize treatment. The goal of this thesis was to tackle those challenges in OSA diagnosis. Additionally, two main algorithmic contributions which are generally applicable were proposed within this thesis. The binary interval coded scoring algorithm was extended to multilevel problems and novel monotonicity constraints were introduced. Moreover, improvements to the random-forest based feature selection were proposed including the use of the Cohen’s kappa value, patient independent validation, and further feature pruning steered by the correlation between features. These novel methods were applied together with classification and feature selection methods from the literature to improve the OSA ...

Historical photos are significant attestations of the inheritance of the past. Since Photography is an art that is more than 150 years old, more and more diffuse are the photographic archives all over the world. Nevertheless, time and bad preservation corrupts physical supports, and many important historical documents risk to be ruined and their content lost. Therefore solutions must be implemented to preserve their state and to recover damaged information. This PhD thesis proposes a general methodology, and several applicative solutions, to handle these problems, by means of digitization and digital restoration. The purpose is to create a useful tool to support non-expert users in the restoration process of damaged historical images. The content of this thesis is outlined as follows: Chapter 1 gives an overview on the problems related to management and preservation of cultural repositories, and discusses about ...

Around 10 percent of all human births is premature, which means that annually about 15 million babies are born before 37 completed weeks of gestation. About one third of the admissions to the Neonatal Intensive Care Unit (NICU) consists of this patient group. Due to complications, 1 million babies die from premature delivery, and it is therefore the most important cause of neonatal death. In general, premature and immature babies have a high risk for neurological abnormalities by maturation in extra-uterine life. Even though improved health care has increased the survival changes of these neonates, they are sensitive to brain damage and consequently, neurocognitive disabilities. Nowadays, critical information about the brain development can be extracted from the electroencephalography (EEG). Clinical experts visually assess evolving EEG characteristics over both short and long periods to evaluate maturation of patients at risk and, ...

Brain disorders represent a significant health challenge. It is estimated that approximately 165 million people suffer from a brain disorder in Europe, while 1 in 3 people will experience such a disorder during their lifetime. Some types of the brain disorders are the following: Alzheimer’s disease, dementias, epilepsy, Parkinson’s disease, Mental disorders, and more. These disorders affect the way people think, feel, or perform daily activities. However, if these disorders are diagnosed early and the person receives suitable medication, their progression may be delayed. For this reason, early diagnosis is crucial. Artificial Intelligence (AI) holds the promise of transforming how we tackle societal issues and enhancing the welfare of both individuals and communities. “AI for Social Good”, also known as “AI for Social Impact” is a new research field aiming to tackle some of the most important social, environmental, and ...

Intravascular ultrasound has, over the past decade, significantly changed the clinical diagnosis and therapeutic strategy of coronary and vascular disease assessment, as it not only allows visualisation of the vessel lumen, but gives a unique view of the pathophysiologic structure of the artery wall. This information is currently unavailable from the universally accepted instrument for artery assessment, angiography, which has on several occasions had its diagnostic accuracy questioned. With intravascular ultrasound, there is the potential to categorise diseased arterial tissue belonging to distinct pathological groups which can ultimately aid in the understanding of individual lesions as well as making a significant contribution to treatment choice and management of cardiac patients. The high resolution image information offered by intravascular ultrasound provides excellent crosssectional views of coronary artery disease at the level of the disease process itself. This information can be used ...

Content Based Image Retrieval (CBIR) has gained a lot of interest over the last two decades. The need to search and retrieve images from databases, based on information (“features”) extracted from the image itself, is becoming increasingly important. CBIR can be useful for handheld image recognition devices in which the image to be recognized is acquired with a camera, and thus there is no additional metadata associated to it. However, most CBIR systems require large computations, preventing their use in handheld devices. In this PhD work, we have developed low-complexity algorithms for content based image retrieval in handheld devices for camera acquired images. Two novel algorithms, ‘Color Density Circular Crop’ (CDCC) and ‘DCT-Phase Match’ (DCTPM), to perform image retrieval along with a two-stage image retrieval algorithm that combines CDCC and DCTPM, to achieve the low complexity required in handheld devices ...

The spectral signatures of the materials contained in hyperspectral images, also called endmembers (EMs), can be significantly affected by variations in atmospheric, illumination or environmental conditions typically occurring within an image. Traditional spectral unmixing (SU) algorithms neglect the spectral variability of the endmembers, what propagates significant mismodeling errors throughout the whole unmixing process and compromises the quality of the estimated abundances. Therefore, significant effort have been recently dedicated to mitigate the effects of spectral variability in SU. However, many challenges still remain in how to best explore a priori information about the problem in order to improve the quality, the robustness and the efficiency of SU algorithms that account for spectral variability. In this thesis, new strategies are developed to address spectral variability in SU. First, an (over)-segmentation-based multiscale regularization strategy is proposed to explore spatial information about the abundance ...

The fact that a third of a human life is spent in a bed indicates the essential character of sleep. While some people might opt voluntarily for sleep deprivation, others don’t get to choose. Their healthy pattern of sleep is disrupted due to sleep disorders such as sleep apnea, insomnia and restless legs syndrome. Most clinical diagnoses revolve around complaints of excessive daytime sleepiness. People usually wait quite long however before contacting professional help, and might only do so when complaints have gone from minor to serious. It can be argued that people with minor complaints will have negligible compliance to rather obtrusive therapies, and should not be treated with pharmaceuticals. However, cognitive and behavioral therapy has proven its effectiveness for clinically diagnosed patients in different domains, and might thus also enhance the quality of life for people with minor ...

Automatic face recognition has attracted a lot of attention not only because of the large number of practical applications where human identification is needed but also due to the technical challenges involved in this problem: large variability in facial appearance, non-linearity of face manifolds and high dimensionality are some the most critical handicaps. In order to deal with the above mentioned challenges, there are two possible strategies: the first is to construct a “good” feature space in which the manifolds become simpler (more linear and more convex). This scheme usually comprises two levels of processing: (1) normalize images geometrically and photometrically and (2) extract features that are stable with respect to these variations (such as those based on Gabor filters). The second strategy is to use classification structures that are able to deal with non-linearities and to generalize properly. To ...

Gait can be defined as the individuals’ manner of walking. Its analysis can provide significant information about their identity and health, opening a wide range of possibilities in the field of biometric recognition and medical diagnosis. In the field of biometric, the use of gait to perform recognition can provide advantages, such as acquisition from a distance and without the cooperation of the individual being observed. In the field of medicine, gait analysis can be used to detect or assess the development of different gait related pathologies. It can also be used to assess neurological or systemic disorders as their effects are reflected in the individuals’ gait. This Thesis focuses on performing gait analysis in unconstrained environments, using a single 2D camera. This can be a challenging task due to the lack of depth information and self-occlusions in a 2D ...

The objectives of the research were to develop embedded and non-embedded lossy coding algorithms for images based on lattice vector quantisation and the discrete wavelet transform. We also wanted to develop context-based entropy coding methods (as opposed to simple first order entropy coding). The main objectives can therefore be summarised as follows: (1) To develop algorithms for intra and inter-band formed vectors (vectors with coefficients from the same sub-band or across different sub-bands) which compare favourably with current high performance wavelet based coders both in terms of rate/distortion performance of the decoded image and also subjective quality; (2) To develop new context-based coding methods (based on vector quantisation). The alternative algorithms we have developed fall into two categories: (a) Entropy coded and Binary uncoded successive approximation lattice vector quantisation (SALVQ- E and SA-LVQ-B) based on quantising vectors formed intra-band. This ...

The subject of this PhD thesis is the efficient and robust processing and analysis of the audio recordings that are derived from a call center. The thesis is comprised of two parts. The first part is dedicated to dialogue/non-dialogue detection and to speaker segmentation. The systems that are developed are prerequisite for detecting (i) the audio segments that actually contain a dialogue between the system and the call center customer and (ii) the change points between the system and the customer. This way the volume of the audio recordings that need to be processed is significantly reduced, while the system is automated. To detect the presence of a dialogue several systems are developed. This is the first effort found in the international literature that the audio channel is exclusively exploited. Also, it is the first time that the speaker utterance ...

The goal of this Ph.D. dissertation is to address a number of challenges encountered in the digital baseband design of modern and future wireless communication systems. The fast and continuous evolution of wireless communications has been driven by the ambitious goal of providing ubiquitous services that could guarantee high throughput, reliability of the communication link and satisfy the increasing demand for efficient re-utilization of the heavily populated wireless spectrum. To cope with these ever-growing performance requirements, researchers around the world have introduced sophisticated broadband physical (PHY)-layer communication schemes able to accommodate higher bandwidth, which indicatively include multiple antennas at the transmitter and receiver and are capable of delivering improved spectral efficiency by applying interference management policies. The merging of Multiple Input Multiple Output (MIMO) schemes with the Orthogonal Frequency Division Multiplexing (OFDM) offers a flexible signal processing substrate to implement ...