In many modern signal processing applications, traditional machine learning and pattern recognition methods heavily rely on the having a sufficiently large amount of data samples to correctly estimate the underlying structures within complex signals. The main idea is to understand the inherent structural information and relationships embedded within the raw data, thereby enabling a wide variety of inference tasks. Nevertheless, the definition of what constitutes a sufficiently large dataset remains subjective and it is often problem-dependent. In this context, traditional learning approaches often fail to learn meaningful structures in the cases where the number of features closely matches (or even exceeds) the number of observations. These scenarios emphasize the need for tailored strategies that effectively extract meaningful structured information from these high-dimensional settings. In this thesis we address fundamental challenges posed by applying traditional machine learning techniques in large dimensional ...

Worldwide approximately 11% of the babies are born before 37 weeks of gestation. The survival rates of these prematurely born infants have steadily increased during the last decades as a result of the technical and medical progress in the neonatal intensive care units (NICUs). The focus of the NICUs has therefore gradually evolved from increasing life chances to improving quality of life. In this respect, promoting and supporting optimal brain development is crucial. Because these neonates are born during a period of rapid growth and development of the brain, they are susceptible to brain damage and therefore vulnerable to adverse neurodevelopmental outcome. In order to identify patients at risk of long-term disabilities, close monitoring of the neurological function during the first critical weeks is a primary concern in the current NICUs. Electroencephalography (EEG) is a valuable tool for continuous noninvasive ...

Obstructive sleep apnea (OSA) is among the most prevalent sleep disorders, which is estimated to affect 6 %−19 % of women and 13 %−33 % of men. Besides daytime sleepiness, impaired cognitive functioning and an increased risk for accidents, OSA may lead to obesity, diabetes and cardiovascular diseases (CVD) on the long term. Its prevalence is only expected to rise, as it is linked to aging and excessive body fat. Nevertheless, many patients remain undiagnosed and untreated due to the cumbersome clinical diagnostic procedures. For this, the patient is required to sleep with an extensive set of body attached sensors. In addition, the recordings only provide a single night perspective on the patient in an uncomfortable, and often unknown, environment. Thus, large scale monitoring at home is desired with comfortable sensors, which can stay in place for several nights. To ...

This thesis focuses on the design of various automatic signal processing algorithms to extract information from physiological signals of preterm infants. Overall, the aim was to improve the neurodevelopmental outcome of the neonate. More specifically, three main research objectives were carried out. The first objective was to describe the maturation of neonates during their stay in the neonatal intensive care unit. The second objective was to assess the stress and pain in premature infants and their impact on the development of neonates. The third objective was to predict developmental disabilities, such as autism. The first part of this thesis presents an extensive overview of various developmental models to describe the maturation of premature infants. Three main strategies were proposed. The first strategy proposed an investigation of EEG connectivity networks. A variety of functional and effective connectivity methods were combined with ...

The theory of statistical signal processing finds a wide variety of applications in the fields of data communications, such as in channel estimation, equalization and symbol detection, and sensor array processing, as in beamforming, and radar systems. Indeed, a large number of these applications can be interpreted in terms of a parametric estimation problem, typically approached by a linear filtering operation acting upon a set of multidimensional observations. Moreover, in many cases, the underlying structure of the observable signals is linear in the parameter to be inferred. This dissertation is devoted to the design and evaluation of statistical signal processing methods under realistic implementation conditions encountered in practice. Traditional statistical signal processing techniques intrinsically provide a good performance under the availability of a particularly high number of observations of fixed dimension. Indeed, the original optimality conditions cannot be theoretically guaranteed ...

The necessity to process signals living in non-Euclidean domains, such as signals de- fined on the top of a graph, has led to the extension of signal processing techniques to the graph setting. Among different approaches, graph signal processing distinguishes it- self by providing a Fourier analysis of these signals. Analogously to the Fourier transform for time and image signals, the graph Fourier transform decomposes the graph signals in terms of the harmonics provided by the underlying topology. For instance, a graph signal characterized by a slow variation between adjacent nodes has a low frequency content. Along with the graph Fourier transform, graph filters are the key tool to alter the graph frequency content of a graph signal. This thesis focuses on graph filters that are performed distributively in the node domain–that is, each node needs to exchange in- formation ...

Fingerprint, is considered one of the most crucial scientific tools in solving criminal cases. This biometric feature is composed of unique and distinctive patterns found on the fingertips of each individual. With advancing technology and progress in forensic sciences, fingerprint analysis plays a vital role in forensic investigations and the analysis of evidence at crime scenes. The fingerprint patterns of each individual start to develop in early stagesof life and never change thereafter. This fact makes fingerprints an exceptional means of identification. In criminal cases, fingerprint analysis is used to decipher traces, evidence, and clues at crime scenes. These analyses not only provide insights into how a crime was committed but also assist in identifying the culprits or individuals involved. Computer-based fingerprint identification systems yield faster and more accurate results compared to traditional methods, making fingerprint comparisons in large databases ...

In multiple-input multiple-output (MIMO) communications systems, the channel state information (CSI) is typically estimated at the receiver side by sending a few known pilots and then used for decoding at the receiver and/or for precoding at the transmitter. These are known as coherent schemes. However, in scenarios dominated by fast fading or massive MIMO systems dedicated to ultra-reliable low-latency communications (URLLC), getting an accurate channel estimate would require pilots to occupy a disproportionate fraction of communication resources. This becomes also a problem in machine-to-machine (M2M) communications that arise in the so-called Internet of Things (IoT). The advent of 5G and beyond (B5G) systems has introduced these novel scenarios that underscore the need for noncoherent communications schemes in which neither the transmitter nor the receiver has any knowledge about the instantaneous CSI. The Grassmannian and Stiefel manifolds play a significant role ...

The ability to hear and process sounds is crucial. For adults, the inevitable ongoing aging process reduces the quality of the speech and sounds one perceives. If this effect is allowed to evolve too far, social isolation may occur. For infants, a disability in processing sounds results in an inappropriate development of speech, language, and cognitive abilities. To reduce the handicap of hearing loss in children, it is important to detect the hearing loss early and to provide effective rehabilitation. As a result, hearing of all newborns needs to be screened. If the outcome of the screening does not indicate normal hearing, more detailed hearing assessment is required. However, standard behavioral testing is not possible, so that assessment has to rely on objective physiological techniques that are not influenced by sleep or sedation. The last few decades, the use of ...

Electroencephalography (EEG) is a non-invasive neurorecording technique, which has the potential to be used for 24/7 neuromonitoring in daily life, e.g., in the context of neural prostheses, brain-computer interfaces, or for improved diagnosis of brain disorders. Although existing mobile wireless EEG headsets are a useful tool for short-term experiments, they are still too heavy, bulky and obtrusive, for long-term EEG-monitoring in daily life. However, we are now witnessing a wave of new miniature EEG sensor devices containing small electrodes embedded in them, which we refer to as Mini-EEGs. Mini-EEGs ideally consist of a wireless node with a small scalp area footprint, in which the electrodes, amplifier and wireless radio are embedded. However, due to their miniaturization, these mini-EEGs have the drawback that only a few EEG channels can be recorded within a small area. The latter also implies that the ...

Epilepsy is one of the most common neurological diseases, especially in children. And although the majority of patients can be treated through medication or surgery (70%-75%), a significant group of patients cannot be treated. For this latter group of patients it is advisable to follow the evolution of the disease. This can be done through a long-term automatic monitoring, which gives an objective measure of the number of seizures that the patient has, for example during the night. On the other hand, there is a reduced social control overnight and the parents or caregivers can miss some seizures. In severe seizures, it is sometimes necessary, however, to avoid dangerous situations during or after the seizure (e.g. the danger of suffocation caused by vomiting or a position that obstructs breathing, or the risk of injury during violent movements), and to comfort ...

Chapter 2 contains a short introduction to the fundamentals of compressed sensing theory, which is the larger context of this thesis. We start with introducing the key concepts of sparsity and sparse representations of signals. We discuss the central problem of compressed sensing, i.e. how to adequately recover sparse signals from a small number of measurements, as well as the multiple formulations of the reconstruction problem. A large part of the chapter is devoted to some of the most important conditions necessary and/or sufficient to guarantee accurate recovery. The aim is to introduce the reader to the basic results, without the burden of detailed proofs. In addition, we also present a few of the popular reconstruction and optimization algorithms that we use throughout the thesis. Chapter 3 presents an alternative sparsity model known as analysis sparsity, that offers similar recovery ...

This Thesis is focused on the use of automatic speaker recognition systems for forensic identification, in what is called forensic automatic speaker recognition. More generally, forensic identification aims at individualization, defined as the certainty of distinguishing an object or person from any other in a given population. This objective is followed by the analysis of the forensic evidence, understood as the comparison between two samples of material, such as glass, blood, speech, etc. An automatic speaker recognition system can be used in order to perform such comparison between some recovered speech material of questioned origin (e.g., an incriminating wire-tapping) and some control speech material coming from a suspect (e.g., recordings acquired in police facilities). However, the evaluation of such evidence is not a trivial issue at all. In fact, the debate about the presentation of forensic evidence in a court ...

Localizing the bioelectric phenomena originating from the cerebral cortex and evoked by auditory and somatosensory stimuli are clear objectives to both understand how the brain works and to recognize different pathologies. Diseases such as Parkinson's, Alzheimer's, schizophrenia and epilepsy are intensively studied to find a cure or accurate diagnosis. Epilepsy is considered the disease with major prevalence within disorders with neurological origin. The recurrent and sudden incidence of seizures can lead to dangerous and possibly life-threatening situations. Since disturbance of consciousness and sudden loss of motor control often occur without any warning, the ability to predict epileptic seizures would reduce patients' anxiety, thus considerably improving quality of life and safety. The common procedure for epilepsy seizure detection is based on brain activity monitorization via electroencephalogram (EEG) data. This process consumes a lot of time, especially in the case of long ...

Obstructive sleep apnea (OSA) is the most prevalent sleep related breathing disorder, nevertheless subjects suffering from it often remain undiagnosed due to the cumbersome diagnosis procedure. Moreover, the prevalence of OSA is increasing and a better phenotyping of patients is needed in order to prioritize treatment. The goal of this thesis was to tackle those challenges in OSA diagnosis. Additionally, two main algorithmic contributions which are generally applicable were proposed within this thesis. The binary interval coded scoring algorithm was extended to multilevel problems and novel monotonicity constraints were introduced. Moreover, improvements to the random-forest based feature selection were proposed including the use of the Cohen’s kappa value, patient independent validation, and further feature pruning steered by the correlation between features. These novel methods were applied together with classification and feature selection methods from the literature to improve the OSA ...